Electronic medical records of four WWE and comorbid CCMs were retrospectively analyzed with attention to comparisons between their pre and perinatal epilepsy burden and CCM characteristics. Childbirth delivery outcomes were also obtained.

All four women (23-28 years old) were found to have no worsening epilepsy control during pregnancy in comparison to their pre-pregnancy seizure burden, though one patient had two breakthrough seizures in the setting of transitioning from Clobazam to Keppra. No hemorrhages were reported during pregnancy in any of the patients. Three of the four women had an uncomplicated vaginal delivery and one had an elective C-section per obstetric concerns for possible hemorrhage during normal delivery or induction. 

The outcomes shown by our case study support the trends of stable CCM and epilepsy courses during pregnancy as outlined by some current literature. Pregnant women with CCMs have similar rates of hemorrhage expansion and seizure frequency as compared to the non-pregnant state, supporting the notion that the presence of CCMs with epilepsy is not a contraindication to pregnancy and the majority of women can have successful vaginal deliveries.