Abstract Details

Title Novel Application of High-density Task-based EEG in DLB

Topic Movement Disorders

Presentation(s) P1 - Poster Session 1 (11:45 AM-12:45 PM)

Poster/Presentation
Number 5-031

Objective

To evaluate task-based electroencephalography (EEG) in dementia with Lewy bodies (DLB)

Background Posterior slowing on EEG during resting-states is a supportive biomarker in DLB. The utility of task-based EEG (tsEEG) paradigms to assess cortical activity in DLB is unclear.

Design/Methods Resting-state (rsEEG) and tsEEG data were collected from 128 channels in 25 cognitively unimpaired adults (mean age 70.1±9.8 years; 40% male) and individuals with DLB or mild cognitive impairment with Lewy bodies (MCI-LB) (6=DLB, 6=MCI-LB; mean age 71.0±6.0 years; 75% male) from the 1Florida Alzheimer’s Disease Research Center (ADRC) at the University of Florida. All participants completed demographic and clinical evaluations. During tsEEG, participants performed a visually guided grip force task with high or low visual gain. Error scores were calculated from the behavioral data, and EEG data were analyzed using a beamformer technique to localize cortical oscillations in time-frequency windows (alpha, beta, theta).

Results DLB/MCI-LB cohort had lower total Montreal Cognitive Assessment (MoCA) scores (20.8±2.6 versus 25.3±2.7; p<0.01). DLB/MCI-LB group had slower peak alpha frequency during rsEEG (7.4±1.1 Hz versus 9.4±1.0 Hz; p<0.001). Individuals with DLB/MCI-LB also exhibited higher offset and steeper slope for aperiodic components during rsEEG. During the grip force task, individuals with DLB/MCI-LB had greater force error, and did not show the expected reduction in error from low to high visual gain that was evident in controls. tsEEG showed a significant group difference where DLB/MCI-LB had an attenuated reduction in low beta power (14-22 Hz) in occipital regions (p_FDR<0.05) compared to the control group, across both visual gain conditions.

Conclusions The rsEEG dominant frequency was significantly slower in DLB/MCI-LB, consistent with prior studies. Individuals with DLB/MCI-LB performed worse during the motor task, possibly modulated by decreased neuronal activation in posterior occipital regions. This is a promising task-based paradigm to better understand changes in cortical neuronal activity in DLB.

Authors/Disclosures
Shannon Y. Chiu, MD, MSc (Mayo Clinic Arizona) PRESENTER	Dr. Chiu has received research support from NIH.
Jinhan Park	Mr. Park has nothing to disclose.
Rachel L. Ho, PhD	Dr. Ho has nothing to disclose.
Sotiris G. Mitropanopoulos, MD (Mayo Clinic)	Dr. Mitropanopoulos has nothing to disclose.
Melissa Armstrong, MD, MSc, FAAN, FAAN (UF Department of Neurology)	The institution of Dr. Armstrong has received research support from National Institutes of Health. The institution of Dr. Armstrong has received research support from Florida Department of Health. The institution of Dr. Armstrong has received research support from Lewy Body Dementia Association. The institution of Dr. Armstrong has received research support from The Michael J. Fox Foundation. Dr. Armstrong has received personal compensation in the range of $5,000-$9,999 for serving as a DSMB member with Alzheimer's Clinical Trials Consortium. Dr. Armstrong has received personal compensation in the range of $5,000-$9,999 for serving as a DSMB member with Alzheimer's Disease Cooperative Study. Dr. Armstrong has received personal compensation in the range of $500-$4,999 for serving as a DSMB member with National Institutes of Health. Dr. Armstrong has a non-compensated relationship as a Member, Scientific Advisory Council with Lewy Body Dementia Association that is relevant to AAN interests or activities.
David Vaillancourt	David Vaillancourt has received personal compensation for serving as an employee of Automated Imaging Diagnostics. David Vaillancourt has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley. The institution of David Vaillancourt has received research support from NIH. David Vaillancourt has received intellectual property interests from a discovery or technology relating to health care.
Stephen Coombes, PhD	Dr. Coombes has received personal compensation in the range of $10,000-$49,999 for serving as a partner with Neuroimaging Solutions LLC.

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