Abstract Details

Title Exploratory Analysis of Comprehensive Neurocognitive Testing in Post-traumatic Brain Injury (TBI) Clinic Patients with Primary Cognitive Symptoms

Topic Neuro Trauma and Critical Care

Presentation(s) P10 - Poster Session 10 (5:00 PM-6:00 PM)

Poster/Presentation
Number 4-004

Objective To assess differences in formal neurocognitive testing in traumatic brain injury (TBI) clinic patients reporting primary cognitive symptoms and analyze predictors of mild-moderate cognitive disorder diagnosis.

Background TBI is a prevalent condition, increasingly recognized as a chronic disease associated with cognitive symptoms and dementia. Screening for post-TBI cognitive disorders is limited in the clinic setting.

Design/Methods Retrospective cohort study of TBI-clinic visits in UCI-NTBIC database (9/2022-8/2024) receiving a standardized neuropsychological battery. Inclusion criteria: ≥18yo, self-reported TBI history (2023-ACRM criteria), cognition as primary symptom. Exclusion: dementia-diagnosis. Outcome is diagnosis of minor or major neurocognitive disorder by neuropsychologist. Descriptive statistics (Mann-Whitney/Fischer-test) and multivariable logistic-regression performed.

Results Of 24 patients with neuropsychology testing (mean age 46, 58% male, 30% non-white race, 83% mild-TBI, mean 31 months post-TBI), 6 (25%) patients were diagnosed with mild (n=5) or moderate (n=1) cognitive disorder secondary to TBI. There were no differences in education or previous TBI severity. Cognitive disorder TBI had higher BMI compared to TBI without cognitive disorder (34 kg/m² SD 9 vs 23 kg/m² SD 3, p=.003). Processing speed index percentile [PSI] (20 SD 35 vs. 58 SD 15 , p= .004) was lower in post-TBI cognitive disorders versus non-cognitive disorders. The trend was indicative of the Montreal Cognitive Assessment [MoCA] (23 SD 3 vs 27 SD .5, p = .013) being lower in cognitive disorder patients; a larger sample size is needed to confirm predictive value. In regression (adjusting for: Age/sex/race/education), time since TBI, PSI and BMI did not independently predict cognitive disorder diagnosis.

Conclusions In chronic TBI clinic patients with primarily cognitive complaints, 25% have a cognitive disorder. Neuropsychology batteries are feasible in a TBI clinic cohort. MoCA and PSI may be useful for cognitive screening and increased BMI may be risk factors for post-TBI cognitive disorder.

Authors/Disclosures
Claire Joyner PRESENTER	Miss Joyner has received research support from National Institute of Health. Miss Joyner has received research support from UCI MIND.
Amanda Fang, Undergraduate student	Miss Fang has nothing to disclose.
Arunima Kapoor	Ms. Kapoor has nothing to disclose.
Alexis Conrad (Neurology Traumatic Brain Injury & Concussion (NTBIC) Program, Department of Neurology, University of California, Irvine, Orange, CA)	No disclosure on file
Bruce Albala, PhD (University of California Irvine)	No disclosure on file
Danh V. Nguyen, PhD	Prof. Nguyen has nothing to disclose.
Michael Lopez, PhD	Michael Lopez has nothing to disclose.
Bernadette Boden-Albala, DrPH (University California Irvine)	Ms. Boden-Albala has received research support from NIH.
Patrick M. Chen, MD (UC Irvine Medical Center)	Dr. Chen has nothing to disclose.

��ɫ��

��ɫ��