Abstract Details

Title Impact of COVID-19 on Stroke Mortality in Patients with Cardiovascular Comorbidities: A 23-Year U.S. Trend Analysis (1999-2022)

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P10 - Poster Session 10 (5:00 PM-6:00 PM)

Poster/Presentation
Number 13-012

Objective To evaluate the impact of the COVID-19 pandemic on stroke mortality rates in patients with comorbid cardiovascular disease (CVD) in the U.S., using CDC WONDER data (1999-2022).

Background

Stroke and CVD are leading causes of mortality. People with CVD have a 2–4 times greater risk of stroke than the general population, placing them at higher risk of severe outcomes, especially during the COVID-19 pandemic. Limited research has explored stroke mortality trends in this vulnerable group in relation to the pandemic.

Design/Methods Mortality data were extracted from CDC WONDER for adults aged 25+ who died from stroke (ICD-10 I60-I69) and comorbid CVD (ICD-10 I00-I99, except I69) from 1999-2022. Mortality rates pre-pandemic (1999-2019) were compared with post-pandemic years (2020-2022). Age-adjusted mortality rates (AAMRs) were calculated, and trends were analyzed using average annual percent changes (AAPCs) with 95% confidence intervals (CI) via Joinpoint Regression.

Results From 1999 to 2019, stroke mortality among patients aged 25+ with comorbid CVD declined with an average annual percent change (AAPC) of -1.75% (95% CI: -2.11 to -1.48). However, during the pandemic (2020-2022), this trend sharply reversed with mortality rates increasing by 5.87% annually (95% CI: 3.96 to 9.09). Males consistently had higher age-adjusted mortality rates (AAMRs) than females (72.2 vs. 64.3 ). The post-COVID rise was more pronounced in males (AAPC: 6.52; 95% CI: 4.17 to 10.26), while females saw a smaller increase (AAPC: 5.87; 95% CI: 3.96 to 9.10). Non-Hispanic (NH) Whites had the highest post-pandemic rise (AAPC: 6.20), followed by NH Blacks (AAPC: 4.36) and Hispanics (AAPC: 2.14).

Conclusions

The COVID-19 pandemic reversed prior declines in stroke mortality among patients with CVD, particularly in males and non-Hispanic Whites. Targeted interventions are needed to mitigate these increased risks in future public health crises.

Authors/Disclosures
Faraz Arshad (Shaikh Zayed Hospital) PRESENTER	Mr. Arshad has nothing to disclose.
Fnu Javairia	Ms. Javairia has nothing to disclose.
Zain A. Nadeem (Allama Iqbal Medical College)	Mr. Nadeem has nothing to disclose.
Javeria Javeid	Mrs. Javeid has nothing to disclose.
Wajeeh Hassan, MBBS	Mr. Hassan has nothing to disclose.
Rohab Sohail, MD	Dr. Sohail has nothing to disclose.

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