Abstract Details

Title Risk of Stroke in Patients with Chagas Disease: A Meta-Analysis of Observational Studies

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P10 - Poster Session 10 (5:00 PM-6:00 PM)

Poster/Presentation
Number 13-013

Objective This systematic review and meta-analysis aimed to evaluate whether Chagas disease infection increases the risk of stroke in patients.

Background Stroke is the second leading cause of death globally, accounting for 11% of all deaths and affecting over 13 million people annually. Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is a neglected tropical disease primarily affecting Latin America but increasingly recognized as a global health issue due to migration and globalization. Chronic Chagas cardiomyopathy, a common outcome of CD, has been suggested to increase the risk of thromboembolic events, including stroke. However, there is limited comprehensive evidence synthesizing the data on this association.

Design/Methods We systematically searched PubMed, Embase, Cochrane Central, and Scielo databases for studies analyzing stroke prevalence in CD patients compared to a control group without CD. Data were examined using the Mantel-Haenszel method, with 95% confidence intervals (CI). Binary endpoints were computed using odds ratio (OR), and statistical analysis was done using RStudio version 4.2.3, with p<0.05 considered statistically significant.

Results

The initial search yielded 2,264 results. After removing duplicates and screening studies based on titles and abstracts, 15 studies met the predefined full-text review criteria. We included 9 studies, involving 4,562 patients (1,738 with CD). Most patients were men, with a mean age of 49-77 years. The pooled analysis indicated that CD patients had a higher risk of stroke compared to the control group (OR 2.08, 95% CI 1.17–3.69; p=0.01). Subgroup analysis of patients with Chagas cardiomyopathy showed a higher stroke risk (OR 1.74, 95% CI 1.02–3.00; p=0.04; I²=51%).

Conclusions

CD is significantly associated with increased stroke risk, particularly in patients with cardiomyopathy. Prospective studies are needed to explore the prognostic significance of cerebrovascular events and the role of therapeutic anticoagulation in primary prevention.

Authors/Disclosures
Victória Siebel PRESENTER	Victória Siebel has nothing to disclose.
Lais T. Reis	Miss Reis has nothing to disclose.
Maria Eduarda Souza	Maria Eduarda Souza has nothing to disclose.
Vitor K. Sano, MS	Mr. Sano has nothing to disclose.
Artur Menegaz de Almeida, MS	Mr. Menegaz de Almeida has nothing to disclose.
Samuel Luca R. Pinheiro	Mr. Pinheiro has nothing to disclose.
Francisco de Moraes	Francisco de Moraes has nothing to disclose.
Francinny A. Kelly, MD	Dr. kelly has nothing to disclose.

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