Abstract Details

Title Assessing the Association Between Immune Dysfunction Conditions and Epilepsy: An Analysis of the 2021 National Health Interview Survey Data

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P11 - Poster Session 11 (8:00 AM-9:00 AM)

Poster/Presentation
Number 9-002

Objective

This study aims to investigate the association between allergies, immune deficiency conditions, and epilepsy, examining whether immune dysfunction contributes to epileptogenesis.

Background

Immunity plays a crucial role in multifactorial disorders such as epilepsy. Emerging studies suggest a potential association between immune-related disorders and epilepsy, indicating that immune dysfunction may influence its development.

Design/Methods We analyzed data from the 2021 National Health Interview Survey (NHIS), including 29,843 adults aged 18–99 years. The study explored the association between epilepsy and allergic conditions such as asthma, food allergies, skin allergies, other respiratory allergies, and immune deficiencies from prescription drugs or other health conditions. Descriptive analysis was conducted using the Rao-Scott Chi² Test, univariate and multivariate logistic regression were applied to adjust for confounders. We utilized Chat GPT 4 to improve clarity and grammar of the text. However, all final content, data interpretations, and conclusions were reviewed and approved by the authors.

Results The lifetime prevalence of epilepsy in the U.S. was 1.7%, with no significant age difference between epileptics and non-epileptics (mean age: 49.58 vs. 48.23 years, p = 0.16). Univariate logistic regression showed significant associations between epilepsy and conditions such as asthma (OR = 1.739, [1.352–2.236]), other respiratory allergies (OR = 1.241, [1.009–1.526]), food allergies (OR = 1.812, [1.365–2.406]), skin allergies (OR = 1.469, [1.105–1.953]), weakened immune systems from prescription drugs (OR = 2.943, [2.125–4.074]), and immune conditions due to other health issues (OR = 3.063, [2.237–4.195]). Adjusted regression remained significant for asthma (OR=1.56, p=0.012), food allergies (OR=1.57,p=0.003), weakened immune system from prescription drugs (OR = 1.78, p=0.04) and immune conditions due to other health issues (OR= 1.96, p=0.023).

Conclusions Individuals with allergic diseases or immune deficiencies have increased odds of developing epilepsy. Further research is necessary to explore the role of immune dysfunction in the pathogenesis of epilepsy.

Authors/Disclosures
Aseel A. Alamri (Taibah University) PRESENTER	Ms. Alamri has nothing to disclose.
Sulaiman Abdullah, MD	Mr. Abdullah has nothing to disclose.
Ahmad Assinnari, MBBS, PhD	Dr. Assinnari has nothing to disclose.

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