Abstract Details

Title Social Determinants of Health in Alzheimer’s Disease Patients from Peru, Nested Study From the Peruvian Alzheimer Disease Initiative (PeADI)

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P11 - Poster Session 11 (8:00 AM-9:00 AM)

Poster/Presentation
Number 3-005

Objective

We aim to identify the main SDOH associated with Alzheimer’s disease (AD) by comparing AD cases to cognitively unimpaired (CU) individuals in the PeADI study.

Background

Social, behavioral and environmental determinants of health (SDOH) such as access to and quality of education and healthcare, and socioeconomic factors influence health outcomes, including dementia.

Design/Methods

The Social Determinants of Brain Health Questionnaire (SDOBH-Q) underwent expert review by local and international neurologists/psychiatrists and local linguistic adaptation. We administer the revised questionnaire to over 100 AD cases and 100 CU individuals from an ongoing genetic study of AD (PeADI) in Peru. This includes participants from three predominantly rural regions in the Andean highlands (Huancayo, Cusco, Puno) and three coastal urban regions (Lima, Callao, Tacna). The association between identified SDOH and AD status will be analyzed using multivariable regressions, adjusted for age, gender, and population substructure.

Results The revised SDOBH-Q questionnaire consists of 15 sections and 79 questions. The pilot assessment was completed by 28 CU volunteers: 17 from Lima and 11 from Huancayo. Preliminary data from the first 60 participants have been collected across regions from both the coast and the Andean highlands of Peru, showing differences between AD and CU regarding neighborhood, education, healthcare access and economic conditions.

Conclusions

SDOH components including neighborhood, education, healthcare access, economic conditions, and environmental factors, may increase the risk of AD in older Peruvian individuals. Gaining a deeper understanding of how genetic and environmental factors interact in the context of AD and related dementias across diverse populations, including Latinos, is critical for future research.

Authors/Disclosures
Maryenela Z. Illanes-Manrique, MD, Atlantic Fellow (Instituto Nacional de Ciencias Neurologicas) PRESENTER	The institution of Dr. Illanes-Manrique has received research support from GLOBAL BRAIN HEALTH INSTITUTE.
Pilar Davila, Bachelor of Public Health	Miss Davila has nothing to disclose.
Midiam Silva-Bullon (Universidad Cientifica del Sur)	No disclosure on file
Larry Adams	No disclosure on file
Sheila C. Suarez, MD (Instituto Nacional De Ciencias Neurologicas)	Dr. Suarez has nothing to disclose.
Julia E. Rios Pinto, Neuropsicóloga	Dr. Rios Pinto has nothing to disclose.
Pedro Mena (University of Miami)	Pedro Mena has nothing to disclose.
Farid Rajabli, PhD (University of Miami)	Farid Rajabli has nothing to disclose.
Katalina McInerney (Fellow, Division of Movement Disorders)	Katalina McInerney has nothing to disclose.
Ivan Cornejo-Herrera, MD (Instituto Nacional De Ciencias Neurologica)	Dr. Cornejo-Herrera has nothing to disclose.
Michael L. Cuccaro	No disclosure on file
Edward Ochoa-Valle (Hospital Regional de Cusco)	Edward Ochoa-Valle has nothing to disclose.
Jeffery Vance, MD, PhD (University of Miami)	Dr. Vance has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for neurology genetics.
Angel Medina-Colque (Direccion Regional de Salud de Puno)	No disclosure on file
Koni Mejia (Daniel Alcides Carrion Hospital)	Dr. Mejia has nothing to disclose.
Elison Sarapura-Castro, MD (Instituto Nacional De Ciencias Neurologicas)	Dr. Sarapura-Castro has nothing to disclose.
Serggio Lanata, MD (UCSF)	Dr. Lanata has nothing to disclose.
Azizi Seixas	No disclosure on file
Margaret A. Pericak-Vance, PhD (University of Miami Miller School of Medicine)	Dr. Pericak-Vance has nothing to disclose.
Mario R. Cornejo Olivas, MD (INSTITUTO NACIONAL DE CIENCIAS NEUROLOGICAS)	Dr. Cornejo Olivas has received research support from UNIVERSIDAD CIENTIFICA DEL SUR. The institution of Dr. Cornejo Olivas has received research support from CHDI. The institution of Dr. Cornejo Olivas has received research support from NIH. The institution of Dr. Cornejo Olivas has received research support from GP2/ASAP/MJFF. Dr. Cornejo Olivas has a non-compensated relationship as a Secretary elect with MDS-PAS that is relevant to AAN interests or activities.

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