To present a rare case of Anton-Babinski syndrome (Anton syndrome) secondary to posterior reversible encephalopathy syndrome (PRES) and to demonstrate the importance of recognizing reversible causes of cortical blindness to improve patient outcomes and guide clinical management.

The etiology of PRES was attributed to chronic chemotherapy toxicity (gemcitabine) and uncontrolled hypertension. Gemcitabine was discontinued, and the patient received anti-seizure and antihypertensive medications. Following treatment, her cortical blindness and confusion improved significantly, although visual hallucinations persisted at discharge but showed signs of reduction.

This case illustrates a rare presentation of Anton syndrome secondary to PRES, emphasizing the need to consider reversible etiologies in cases of cortical blindness. Early recognition and management of PRES—through effective control of blood pressure and discontinuation of neurotoxic medications—can lead to good clinical outcomes, even in severe cases involving seizures and cortical blindness.