Abstract Details

Title Remote Multi-modal Monitoring in ALS Using Wearable and Digital Assessments

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P11 - Poster Session 11 (8:00 AM-9:00 AM)

Poster/Presentation
Number 11-010

Objective To develop and validate a remote monitoring system using wearable and digital assessments to track disease progression and symptoms in individuals with amyotrophic lateral sclerosis (ALS)

Background A comprehensive assessment of neurological symptoms and disease progression can improve patient care and readiness for clinical trials in ALS. This study developed a remote monitoring system using wearable technology to track changes in physical activity, fine motor function, patient-reported outcomes (PROs), and speech in individuals with ALS.

Design/Methods

ALS participants were followed for up to 12 months, with clinical visits at baseline and every three months. After each visit, participants wore a PAMSys™ pendant and two PAMSys ULM™ wrist sensors to monitor daily physical activity and hand movements for one week. Bi-weekly digital assessments of speech, handwriting, and pattern-tracing were conducted using BioDigit Home tablets. Data were analyzed using repeated measures correlation and linear mixed models.

Results

Data from 18 ALS participants (mean age 66.3 ± 9.6 years; 6 females) across 51 visits were analyzed. Physical activity sensor data correlated significantly with ALSFRS-R gross motor scores (r = 0.41 to 0.60, p < 0.05). Speech metrics, including articulatory rate and intelligibility, showed moderate to strong associations with ALSFRS-R bulbar and respiratory scores. High compliance rates were observed: 91.9% for speech tasks, 96.5% for pendant sensors (>18 hours worn), and 88% for handwriting and pattern-tracing tasks.

Conclusions These pilot results demonstrate the feasibility of multi-modal, at-home monitoring for ALS. Digital assessments offer objective measurement, high compliance, scalability, and cost-effectiveness, supporting efforts to improve ALS care and health equity.

Authors/Disclosures
Ashkan Vaziri, PhD (Biosensics LLC) PRESENTER	Dr. Vaziri has received personal compensation for serving as an employee of Biosensics.
Ram Kinker Mishra, PhD (Biosensics)	Dr. Mishra has received personal compensation for serving as an employee of BioSensics LLC.
Adonay Nunes (Biosensics)	Adonay Nunes has nothing to disclose.
Zachary Simmons, MD, FAAN (Penn State Hershey Med Center)	Dr. Simmons has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Amylyx. Dr. Simmons has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Clene. Dr. Simmons has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Insmed. Dr. Simmons has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Simmons has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Corcept. The institution of Dr. Simmons has received personal compensation in the range of $50,000-$99,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley. The institution of Dr. Simmons has received research support from MGH. The institution of Dr. Simmons has received research support from Clene. The institution of Dr. Simmons has received research support from NIH via MGH. The institution of Dr. Simmons has received research support from Aburo. The institution of Dr. Simmons has received research support from NIH subaward via Univ of Pennsylvania.
Andrew Geronimo	The institution of Andrew Geronimo has received research support from BIoSensics.

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