Epilepsy remains a significant public health concern in sub-Saharan Africa (SSA) where diverse etiological factors contribute to its prevalence. Among these factors are conditions originating from the neuroectoderm, such as tuberous sclerosis. Insufficient medical attention and a lack of comprehensive multidisciplinary care contribute to its under-recognition.

During the study, twelve cases involving seven boys and five girls (aged 13 months to 14 years) were documented. All consultations were triggered by epileptic seizures, many suggesting frequent status epilepticus due to inadequate treatment. Family history showed paroxysmal episodes in parents of four cases, though details were lacking. Dermatological signs included facial angiofibroma in two patients and shagreen patches in one. Five patients had West syndrome, three had Lennox-Gastaut syndrome, and four experienced partial seizures that became generalized. Nine patients had neurodevelopmental disorders like autism and delayed development. A cardiac hamartoma was diagnosed in one patient. Two cases involved intracranial aneurysms associated with subependymal giant cell astrocytomas (SEGA). Cognitive impairments worsened due to delayed treatment. Autism was noted in four patients, and one case showed normal development

The study reveals a consistent clinical presentation accompanied by deteriorating neurological and psychological symptoms attributed to delayed multidisciplinary management. These findings are utilized to assess therapeutic strategies and prognostic outcomes.