Abstract Details

Title Diagnostic Value of Cerebral Peduncle Diameter in Amyotrophic Lateral Sclerosis Using Transcranial Ultrasound

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P11 - Poster Session 11 (8:00 AM-9:00 AM)

Poster/Presentation
Number 11-024

Objective The current study aimed to evaluate the corticospinal tract detected by sonography as a biomarker in
ALS patients.

Background Corticospinal tract degeneration measured by magnetic resonance
imaging (MRI) was previously reported in the amyotrophic lateral sclerosis (ALS) group.

Design/Methods The study was prepared using the Standards for Reporting of Diagnostic Accuracy
(STARD) checklist. 15 ALS and 25 age-matched healthy individuals were enrolled in this study.
The cerebral peduncle diameter was recorded by transcranial B-mode sonography. Moreover, the
association of cerebral peduncle diameter with disease severity adjusted by age and sex was
assessed through ordinal regression.

Results The average diameter of the cerebral peduncle in ALS patients was significantly lower
than in the control group (1.20 ± 0.21 cm, 1.31 ± 0.11 cm; p=0.013). Although there was a
significant difference in the right cerebral peduncle diameter, the left cerebral diameter was not
significantly different. In addition, by stratifying patients into four grades based on disease
severity, a positive significant association was revealed between the disease severity assessed by
the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-r) score and the
cerebral peduncle diameter (Wald: 6.040; OR: 1.609, 95% CI [1.101-2.350]).

Conclusions The results of this study specified cerebral peduncle as a biomarker for ALS
disease. Evaluating cerebral peduncles in ALS patients to determine the disease progression over
time is suggested for further study.

Authors/Disclosures
Aida Akhoundi, MD PRESENTER	Dr. Akhoundi has nothing to disclose.
Armin Ariaei (Iran University of Medical Sciences)	Mr. Ariaei has nothing to disclose.
Davoud Kamali, MD	Dr. Kamali has nothing to disclose.
Maryam Rezaee, MD	Dr. rezaee has nothing to disclose.
Bahram Haghi Ashtiani, MD	Dr. Haghi Ashtiani has nothing to disclose.
Mohamad Taghi Tajik Jalayeri, MD	Dr. tajik jalayeri has nothing to disclose.
Alireza Salmanipour, MD	Dr. Salmanipour has nothing to disclose.

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