Abstract Details

Title Intermittent Calorie Restriction for Relapsing-remitting Multiple Sclerosis- A Systematic Review and Meta-analysis

Topic Multiple Sclerosis

Presentation(s) P12 - Poster Session 12 (11:45 AM-12:45 PM)

Poster/Presentation
Number 1-002

Objective

We aimed to perform a meta-analysis of metabolic endpoints from studies comparing intermittent calorie restriction (iCR) with a regular diet for patients with relapsing-remitting multiple sclerosis (RRMS).

Background

ICR is a diet therapy that has been studied for treatment of RRMS. Understanding the effects of iCR in metabolic parameters is critical considering the long treatment durations associated with multiple sclerosis.

Design/Methods We searched Pubmed, Embase and Cochrane Central for studies comparing iCR to an unrestricted diet in patients with RRMS treated with disease-modifying therapy (DMT). Primary outcomes were serum leptin and adiponectin levels. Statistical analysis was performed using R Studio 4.3.1. Heterogeneity was assessed with I² statistics.

Results In our analysis, 1,150 articles were identified, of which we included three studies, comprising a total of 66 patients, of which iCR was the treatment option in 34 (51.51%) patients. Leptin (SMD 0.06; 95% CI [-1.34;1.47]; p=0.93; I²=86%) and adiponectin (SMD 1.35; 95% CI [-2.58; 5.29]; p=0.50; I²=92%) both had no clinical difference between the intervention and the control group.

Conclusions We cannot definitively ascertain the impact of iCR on adiponectin and leptin levels among RRMS patients. Further research is warranted to provide a clearer understanding of this intervention's metabolic effect.

Authors/Disclosures
Felipe A. Gouhie PRESENTER	Mr. Gouhie has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Marjan Farma.
Laura Finn, MD	Miss Finn has nothing to disclose.
Lucas B. Kotecki	Mr. Kotecki has nothing to disclose.
Fatima V. Leite, Medical student (MS)	Miss Leite has nothing to disclose.
Pedro Grossi	Mr. Grossi has nothing to disclose.
Anna V. de Vasconcelos	Miss de Vasconcelos has nothing to disclose.

��ɫ��

��ɫ��