A 30-year-old woman first presented with acute disseminated encephalomyelitis (ADEM) at age 4. Over the next 18 years, she experienced over 10 relapses (involving unilateral or bilateral optic neuritis [ON], brainstem syndromes, and one cerebral syndrome) before achieving remission with intravenous immunoglobulin G. At age 16, she tested positive for serum anti-MOG antibodies. She was later diagnosed with psoriasis and SS.

Literature review identified four additional patients (three [75%] female) with concurrent MOGAD and SS, who ranged in age from 13-45 years at neurologic presentation. MOGAD syndromes included ON in two (50%) patients: one with longitudinally extensive ON, and one with bilateral ON then unilateral ON several years later. Two (50%) patients had transverse myelitis: one was longitudinally extensive, and the other involved the conus. Three (75%) patients had monophasic courses at 1-6 years of follow-up, while one (25%) patient experienced one relapse. Acute treatment involved steroids in all four cases, with the addition of PLEX in one case. Only one patient was treated with chronic immunotherapy (one year of azathioprine). Though our patient developed permanent visual deficits, outcomes in the other patients were favorable.