Abstract Details

Title Prevalence of Large Vessel Occlusion (LVO) in Latin American Patients with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P12 - Poster Session 12 (11:45 AM-12:45 PM)

Poster/Presentation
Number 14-006

Objective To summarize the current evidence about prevalence and risk factors of LVO in Latin America patients with acute ischemic stroke.

Background LVOs usually represent up to 30% of ischemic strokes, showing a similar incidence in Latin American populations, and their management may vary according to access to specialized diagnosis and treatment, for which reason the evidence is scarce.

Design/Methods We systematically searched 6 databases up to July 2024 for studies evaluating Latin America patients with acute ischemic stroke that develop a LVO. A meta-analysis using a random-effects model to estimate pooled effects was planned for each outcome and a narrative synthesis when this was not possible. The risk of bias was assessed according to Joanna Briggs Institute (JBI) guidelines for prevalence studies and GRADE criteria were used to identify the certainty of evidence (CoE).

Results After selection, we included 17 studies with a higher number of men (52.6%) and an average age of 62.5 years. All studies had a low risk of bias. The overall prevalence of LVO was 92.0% (13221 participants; 95% CI: 63.0%-99.0%; I2 = 98%; CoE very low), with a higher proportion in Brazil (96.0%; 12 studies; 5441 participants; 95% CI: 78.0%-99.0%; I2 = 97%; CoE very low). At 3 months, 20.0% died (1765 participants; 95% CI: 11.0%-31.0%; I2 = 97%; CoE very low) and only 46% had a good prognosis (2269 participants; 95% CI: 35.0%-57.0%; I2 = 96%; CoE very low).

Conclusions We found that almost all patients with acute ischemic stroke were due to LVO and that less than half of the patients had favorable outcomes at 3 months; however, the very low certainty and small number of studies indicate that further studies should be conducted to corroborate our results.

Authors/Disclosures
Niels V. Pacheco, MD PRESENTER	Mr. Pacheco has nothing to disclose.
Karlos A. Acurio, MD (Universidad Peruana Cayetano Heredia)	Mr. Acurio has nothing to disclose.
Fritz F. Vascones Roman, Sr.	Mr. Vascones Roman has nothing to disclose.
Wagner Rios-Garcia	Mr. Rios-Garcia has nothing to disclose.
Zinnia Brenda B. Cuyotupa Cosme	Zinnia Brenda B. Cuyotupa Cosme has nothing to disclose.
Irving G. Calisaya-Madariaga, Sr. (Universidad Peruana Cayetano Heredia)	Mr. Calisaya-Madariaga has nothing to disclose.
Andre Lapeyre Rivera	Mr. Lapeyre Rivera has nothing to disclose.
Diana Carolina Salazar Flores, MD	Dr. Salazar Flores has nothing to disclose.
Ariana Alvarez-Rojas, Student	Miss Alvarez-Rojas has nothing to disclose.
Lyan Chang, MD	Dr. Chang has nothing to disclose.
Carlos Rodrigo Q. Vicuña	Mr. Vicuña has nothing to disclose.
Olivier Uwishema, MD (Oli Health Magazine Organization (OHMO))	Dr. Uwishema has nothing to disclose.

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