Abstract Details

Title Comparison Between Left and Right Hemisphere DTI-ALPS Indices and Associated Measurements in Healthy Subjects

Topic General Neurology

Presentation(s) P12 - Poster Session 12 (11:45 AM-12:45 PM)

Poster/Presentation
Number 2-006

Objective To evaluate the differences of diffusion tensor imaging analysis along perivascular space (DTI-ALPS) indices and related DTI measurements between the dominant and non-dominant hemispheres in healthy volunteers.

Background The brain asymmetry may affect the DTI-ALPS indices and the related DTI measurements in the dominant or non-dominant hemispheres.

Design/Methods DTI data were acquired from 10 right-handed healthy volunteers (mean age 31.5±9.3, 6 females). Following data correction, DTI measurement maps, including fractional anisotropy (FA), mean diffusivity (MD), and tensor maps, were generated and registered to the FMRIB58_FA (1mm) template. Four 5mm-diameter spherical regions of interest (ROIs) were set in the left and right projection and association fibers. The DTI-ALPS indices and related DTI measurements (FA, MD, λ1, λ2, λ3, Dxx, Dyy, Dzz) for each ROI were compared between the left and right sides using a paired t-test.

Results The left-sided (dominant hemisphere) ALPS indices were significantly higher than the right-sided (non-dominant hemisphere) indices (1.655±0.137 vs. 1.560±0.148, t = 2.461, P = 0.036). The λ3 in the left-sided projection fibers was significantly lower than in the right-sided fibers (0.370±0.016 vs. 0.393±0.018, t = -3.052, P = 0.014). No statistically significant differences were observed for other DTI measurements.

Conclusions The results demonstrate significant differences in DTI-ALPS indices and λ3 measurements of projection fibers between the dominant and non-dominant hemispheres in healthy right-handed volunteers. The higher ALPS indices in the left hemisphere suggest potential differences in perivascular space structure or function, while the lower λ3 in left-sided projection fibers may indicate variations in white matter microstructure. These findings underscore the importance of considering brain asymmetry when interpreting DTI measurements in research settings. Further studies with larger sample sizes and diverse hand dominancy populations are needed to corroborate these findings and elucidate their implications.

Authors/Disclosures
Hsiangkuo Yuan, MD, PhD (Jefferson Headache Center) PRESENTER	An immediate family member of Dr. Yuan has received personal compensation for serving as an employee of Merck. Dr. Yuan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Pfizer. Dr. Yuan has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Yuan has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pfizer. Dr. Yuan has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Salvia. Dr. Yuan has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cerenovous. Dr. Yuan has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Regional Anesthesia and Pain Medicine. Dr. Yuan has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Current Headache and Pain Reports. Dr. Yuan has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for MedLink Neurology. Dr. Yuan has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Cephalalgia. The institution of Dr. Yuan has received research support from NIH. The institution of Dr. Yuan has received research support from American Headache Society. The institution of Dr. Yuan has received research support from Pfizer. Dr. Yuan has received publishing royalties from a publication relating to health care. Dr. Yuan has received publishing royalties from a publication relating to health care. Dr. Yuan has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH. Dr. Yuan has received personal compensation in the range of $10,000-$49,999 for serving as a Invited speaker with Chinese Stroke Association.
Enchao Qiu (Jefferson Headache Center)	Enchao Qiu has nothing to disclose.
Phillip Phan	Mr. Phan has nothing to disclose.
Areeba Nisar, MD	Dr. Nisar has nothing to disclose.
Mahdi Alizadeh, PhD	Dr. Alizadeh has nothing to disclose.
Devon Middleton, PhD	Dr. Middleton has received intellectual property interests from a discovery or technology relating to health care.
Feroze Mohamed, PhD	The institution of Prof. Mohamed has received research support from NIH. Prof. Mohamed has received intellectual property interests from a discovery or technology relating to health care. Prof. Mohamed has received publishing royalties from a publication relating to health care.
Joga Chaganti (Thomas Jefferson University Hospital)	Joga Chaganti has nothing to disclose.
Kiran Talekar	An immediate family member of Kiran Talekar has received personal compensation for serving as an employee of Verismo. An immediate family member of Kiran Talekar has received personal compensation for serving as an employee of GSK Pharmaceuticals. An immediate family member of Kiran Talekar has stock in GSK. The institution of Kiran Talekar has received research support from NIH. The institution of Kiran Talekar has received research support from Gates Foundation. An immediate family member of Kiran Talekar has received intellectual property interests from a discovery or technology relating to health care.
Prabath Mondel (Thomas Jefferson University Hospital)	Prabath Mondel has nothing to disclose.
Scott Faro	Scott Faro has nothing to disclose.

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