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Abstract Details

Endovascular Treatment versus Medical Treatment for Basilar Artery Occlusion: A Systematic Review and Meta-Analysis
Cerebrovascular Disease and Interventional Neurology
P12 - Poster Session 12 (11:45 AM-12:45 PM)
13-011
This systematic review and meta-analysis aims to compare the efficacy and safety of ET versus SMT in BAO patients, assessing their impact on clinical outcomes.
Basilar artery occlusion (BAO) is a severe type of stroke associated with high mortality and poor neurological outcomes. Despite advancements in endovascular treatment (ET), its superiority over standard medical therapy (SMT) remains uncertain.

We conducted systematic searches in PubMed, Cochrane, and Embase databases for randomized controlled trials (RCTs) comparing ET and SMT in BAO patients. The selected outcomes were mortality, successful reperfusion, and neurological outcomes at 90 days. Pooled analyses used fixed effects models, calculating 95% confidence intervals (CIs). Heterogeneity was assessed using I² statistics. Statistical analyses were performed using R software, version 4.4.1.

Eight studies met the inclusion criteria, with 1,200 patients in the endovascular treatment group and 555 in the SMT control group. The analysis demonstrated a significant reduction in mortality with ET compared to SMT (0% vs. 44%; OR 0.44; 95% CI (0.30 to 0.65); P < 0.0001). Secondary outcomes also favored ET, showing higher successful reperfusion rates (OR = 3.36, 95% CI [1.98; 5.70], P < 0.01) and better neurological outcomes at 90 days (OR = 1.54, 95% CI [1.10; 2.17], P < 0.05).
This meta-analysis demonstrates that ET offers significant advantages over SMT for patients with BAO, leading to lower mortality and better neurological outcomes. Given this evidence, ET could be considered a preferred treatment option. Further research is needed to understand long-term effects and manage potential complications.
Authors/Disclosures
Artur Menegaz de Almeida, MS
PRESENTER 		Mr. Menegaz de Almeida has nothing to disclose.
Hamilton Roberto Moreira de Oliveira Carrico Mr. Roberto Moreira de Oliveira Carrico has nothing to disclose.
Nuris M. Torres Argota, Sr. Dr. Torres Argota has nothing to disclose.
Helen C. Beckert Miss Beckert has nothing to disclose.
Larissa E. Tanimoto, student Miss Tanimoto has nothing to disclose.
Andressa G. Cardoso, Medicine student Mrs. Cardoso has nothing to disclose.
Francisco Jose Germano Hennemann Mr. Germano Hennemann has nothing to disclose.
Paulo M. Cruz, Sr., Student Mr. Cruz has nothing to disclose.