Abstract Details

Title Pharmacological Interventions for Symptomatic Management of Neuromyelitis Optica Spectrum Disorder (NMOSD) : A Network Meta-analysis of Randomised Controlled Trials

Topic Autoimmune Neurology

Presentation(s) P12 - Poster Session 12 (11:45 AM-12:45 PM)

Poster/Presentation
Number 8-014

Objective To evaluate the efficacy of pharmacological interventions in managing Neuromyelitis Optica Spectrum Disorder (NMOSD) symptoms through a network meta-analysis (NMA) and systematic review.

Background Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune condition affecting the optic nerves and spinal cord, leading to significant neurological deficits. Treatments like rituximab and eculizumab help reduce relapses, but further research is essential to optimize therapeutic strategies and enhance long-term patient outcomes

Design/Methods To evaluate the efficacy of pharmacological interventions in managing Neuromyelitis Optica Spectrum Disorder (NMOSD) symptoms through a network meta-analysis (NMA) and systematic review.

Results Satralizumab marginally improves disability scores over placebo, evidenced by a small and statistically insignificant effect size (SMD = 0.25, 95% CI -0.17 to 0.68). Eculizumab significantly reduced relapse rates compared to placebo (SMD = -0.35, 95% CI -0.70 to 0.00), with the ranking plot confirming its superiority in this outcome (P-score = 0.941).

Conclusions In conclusion, the NMA demonstrates variable efficacy of different treatments for NMOSD across several symptomatic outcomes. Ravulizumab emerges as the most effective treatment for reducing disability, while Eculizumab leads in preventing relapses.

Authors/Disclosures
Malavika Rudrakumar (St. John's medical college) PRESENTER	Miss Rudrakumar has nothing to disclose.
Aman M. Bhonsale, MBBS (All India Institute of Medical Sciences, Nagpur)	Mr. Bhonsale has nothing to disclose.
Suhrud Panchawagh, MBBS	Dr. Panchawagh has nothing to disclose.
Sanskruti Mote (All India Institute of Medical Sciences, Nagpur)	No disclosure on file
Anmol Kaur (Lady Hardinge Medical College and Associated Hospitals)	Miss Kaur has nothing to disclose.
Ansh B. Gadhiya, Jr., MBBS	Mr. Gadhiya has nothing to disclose.
Mokshita R. Gundlagutta, MBBS	Miss Gundlagutta has nothing to disclose.
Himanshu Garg II, MBBS	Dr. Garg has nothing to disclose.
Khushi S. Sonchhatra, MBBS	Miss Sonchhatra has nothing to disclose.
Uditha S. Kolamala, MBBS	Miss Kolamala has nothing to disclose.

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