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Abstract Details

Clinical Outcomes and Events in a United States Generalized Myasthenia Gravis Population: Analysis of Real-world Data
Neuromuscular and Clinical Neurophysiology (EMG)
P12 - Poster Session 12 (11:45 AM-12:45 PM)
11-032
To describe real-world clinical status and treatment patterns for a generalized myasthenia gravis (gMG) population in the United States (US).
gMG is a chronic autoimmune condition caused by pathologic autoantibodies that disrupt neuromuscular transmission, causing muscle weakness and fatigue. Treatments aim to improve clinical outcomes and reduce the frequency of exacerbations and life-threatening myasthenic crises.
Data were drawn from the Adelphi Myasthenia Gravis (MG) II Disease Specific Programme, with US data collected from February through August 2024.

Overall, 49 physicians reported on 312 patients with gMG (mean [SD] age, 55.5 [14.2] years; 53.2% male; 79.8% Caucasian/White). Patients had a mean (SD) time since diagnosis of 4.0 (5.3) years, 71.8% were anti-acetylcholine receptor antibody-positive, and 75.3% had comorbidities, most frequently hypertension (39.1%). Most patients were Myasthenia Gravis Foundation of America Class II or above (78.5%), and the mean (SD) MG-Activities of Daily Living (MG-ADL) score was 4.1 (3.1); mean MG-ADL scores in patients aged <50 and ≥50 years were 3.8 (2.9) and 4.3 (3.3), respectively. Patients had tried a mean (SD) of 1.6 (1.0) treatment regimens, and 81.7% were receiving maintenance treatment, with 46.3% receiving novel therapies (complement inhibitors, 16.5%; neonatal Fc receptor inhibitors, 15.7%; immunoglobulins, 12.5%). Exacerbation and myasthenic crisis since diagnosis were reported for 28.9% and 13.4% of patients, respectively; 45.6% of those with an exacerbation and 31.4% of those with a crisis experienced an event in the prior 12 months. Overall, 14.9% of patients had ≥1 MG-related hospitalization in the prior 12 months, and 17.3% had undergone thymectomy. 
Despite the use of novel therapies, patients with gMG continue to experience clinical exacerbations and myasthenic crises, highlighting suboptimal disease control. Further longitudinal analyses are required to understand the real-world impact of new and emerging therapies on clinical outcomes, as well as the associated costs.
Authors/Disclosures
Lesley-Ann 9. Miller-Wilson, PhD (Immunovant)
PRESENTER
Dr. Miller-Wilson has received personal compensation for serving as an employee of Immunovant Inc. Dr. Miller-Wilson has or had stock in Immunovant Inc..
Lincy Lal, PhD Mrs. Lal has received personal compensation for serving as an employee of Immunovant. Mrs. Lal has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant with UT School of Public Health.
Joe Conyers Mr. Conyers has nothing to disclose.
Shiva L. Birija, BSc Miss Birija has nothing to disclose.
Ciara Ringland Miss Ringland has nothing to disclose.
Hannah Connolly (Adelphi Real World) Hannah Connolly has nothing to disclose.
Gregor Gibson (Adelphi Real World) Mr. Gibson has nothing to disclose.
NIALL HATCHELL (ADELPHI REAL WORLD) Mr. HATCHELL has nothing to disclose.
Yuriy Edwards, MD, PhD Dr. Edwards has received personal compensation for serving as an employee of Immunovant. Dr. Edwards has stock in Immunovant.