Abstract Details

Title Higher Serum Vitamin B6 and B12 Levels Associated with Parkinson’s Disease Incidence

Topic Movement Disorders

Presentation(s) P2 - Poster Session 2 (8:00 AM-9:00 AM)

Poster/Presentation
Number 5-003

Objective

To assess the association of baseline serum vitamin B12, B6, and folate levels on risk of incident Parkinson’s disease (PD) among participants in the Framingham Heart Study (FHS).

Background B vitamins (B12, B6, folate) have been proposed as protective against developing PD. Higher intake of B12 and B6 is associated with lower PD risk and folate and vitamin B12 levels are lower in people with PD. Given substantial variability between vitamin intake and serum levels, we sought to determine associations between serum vitamin levels collected in unaffected individuals and risk of incident PD.

Design/Methods

We analyzed prospectively collected data in the Original (exam 20: 1986-1990) and Offspring (exam 5: 1991-1995) cohorts from the FHS. Participants were included if data were available for PD diagnosis status, baseline serum vitamin levels (B12, B6, folate), and food frequency questionnaire (FFQ). Exclusion criteria included PD diagnosis at FHS entry or within 5 years. Dietary intake of vitamins was ascertained using FFQ. Primary outcome measure was PD incidence. Results were adjusted for age, sex, dietary intake, and cohort effect. Similar analyses were completed for incident all-cause dementia and Alzheimer’s disease.

Results 2,757 participants (mean age 59.7[SD, 12.4], 45.8% men) followed on average for 19.4[SD, 6.1] years were included. With surveillance beginning 5 years after entry, there were 40 incident PD cases. The highest tertiles of serum B12 (HR 2.27 [95% CI 1.04, 4.95], p=0.040) and B6 (HR 2.96 [1.24, 7.07], p=0.015) levels were associated with incident PD, but not vitamin intake. Higher serum vitamin levels were not associated with incident dementia or Alzheimer’s disease. Higher dietary intake of vitamins was not associated with incident PD.

Conclusions

In this longitudinal population study, higher B12 and B6 serum levels were associated with an increased risk of incident PD. The reasons for this unexpected association are unknown and require further investigation.

Authors/Disclosures
Sarah Horn, MD (UT Health San Antonio) PRESENTER	Dr. Horn has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AbbVie. The institution of Dr. Horn has received research support from Alzheimer's Association.
Rebecca Bernal, MS	Ms. Bernal has nothing to disclose.
Chadwick W. Christine, MD, FAAN	The institution of Dr. Christine has received research support from Michael J Fox Foundation for Parkinson's Research. The institution of Dr. Christine has received research support from Aspen Neurosciences. The institution of Dr. Christine has received research support from ASK BIo. The institution of Dr. Christine has received research support from Bayer.
Alexa Beiser	Alexa Beiser has nothing to disclose.
Sudha Seshadri, MD, FAAN (Glenn Biggs Institute for Alzheimer'S and Neurodegenerative Diseases)	Dr. Seshadri has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Seshadri has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. The institution of Dr. Seshadri has received research support from NIH. The institution of Dr. Seshadri has received research support from Alzheimer Association.
Debora Melo van Lent (UT Health San Antonio, Biggs Institute, McDermott Building)	The institution of an immediate family member of Debora Melo van Lent has received research support from NIH. The institution of Debora Melo van Lent has received research support from Alzheimer's Assocation.
Jayandra Himali	Jayandra Himali has nothing to disclose.

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