Abstract Details

Title Proximity to, and Presence of, Golf Courses on Vulnerable and Non-vulnerable Groundwater Service Areas and Risk of Parkinson Disease in a Population-based Study

Topic Movement Disorders

Presentation(s) P2 - Poster Session 2 (8:00 AM-9:00 AM)

Poster/Presentation
Number 5-005

Objective To investigate residential proximity to golf courses and the potential for groundwater contamination on Parkinson’s disease (PD) risk.

Background The role of pesticide exposure from golf courses on PD risk remains unclear.

Design/Methods We performed a population-based case-control study of 419 incident PD patients and 5,113 matched controls in the 27-county Rochester Epidemiology Project study area. Exposures included residential distance to golf courses, residence in water service areas containing a golf course, and residence in vulnerable groundwater regions. All models adjusted for age, sex, race, year of index, median household income, and urban/rural.

Results After adjusting for patient demographics, median income, and rural/urban living, proximity to a golf course was associated with increased PD risk. Individuals living within 1 mile of a golf course had 126% increased odds of PD compared to those living farther than 6 miles away from a golf course (aOR = 2.26, 95% CI: 1.09 – 4.70). Individuals living within water service areas with a golf course had nearly double the odds of PD compared to individuals in water service areas without golf courses (aOR=1.96, 95% CI 1.20-3.23) and 49% greater odds compared to individuals with private wells (95% CI 1.05–2.13). Additionally, individuals living in water service areas with a golf course in vulnerable groundwater regions had 82% greater odds of PD compared to those in non-vulnerable groundwater regions (aOR=1.82, 95% CI 1.09-3.03). Our analysis of municipal wells revealed no association between PD risk and living in water service areas with shallow municipal wells (aOR = 0.63, 95% CI: 0.24-1.64).

Conclusions The greatest risk of PD was found within 1 to 3 miles of a golf course and risk generally decreased with distance. The strongest associations were in water service areas with a golf course and in water service areas on vulnerable groundwater regions.

Authors/Disclosures
Brittany Krzyzanowski, PhD PRESENTER	Dr. Krzyzanowski has nothing to disclose.
Aidan Mullan (Mayo Clinic)	Aidan Mullan has nothing to disclose.
E. Ray Dorsey, MD, MBA (University of Rochester)	Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Seelos Therapeutics. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eden McCallum, LLP. Dr. Dorsey has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Genentech/Roche. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biohaven Pharmaceuticals. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for WebMD. Dr. Dorsey has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for BioSensics. Dr. Dorsey has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Mediflix. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cerevance. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Kairos Cinema, LLC. Dr. Dorsey has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Mitsubishi Tanabe Pharma America Inc.. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for HanAll. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Dorsey has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Advarra. Dr. Dorsey has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medrhythms. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for ANA. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for HMP ��ɫ��, LLP. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for ADIVO Associates France. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for University of Toronto. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philadelphia Neurological Society. Dr. Dorsey has stock in Included Health. Dr. Dorsey has stock in Mediflix. Dr. Dorsey has stock in SemCap. Dr. Dorsey has stock in Synapticure. The institution of Dr. Dorsey has received research support from NIH/NINDS. The institution of Dr. Dorsey has received research support from Burroughs Wellcome . The institution of Dr. Dorsey has received research support from Michael J. Fox Foundation - Fox Insight. The institution of Dr. Dorsey has received research support from Michael J. Fox Foundation - Emerald. The institution of Dr. Dorsey has received research support from B. Thomas Golisano Foundation. The institution of Dr. Dorsey has received research support from Emerald Innovations, Inc.. The institution of Dr. Dorsey has received research support from Photopharmics Inc.. The institution of Dr. Dorsey has received research support from Averitas Pharma Inc.. The institution of Dr. Dorsey has received research support from DOD/Army Medical Research Acquisition Activity. The institution of Dr. Dorsey has received research support from NIH/NINDS.
Sai Shivani Chirag, MS	Miss Chirag has nothing to disclose.
Pierpaolo Turcano, MD (Rush University Medical Center)	Dr. Turcano has nothing to disclose.
Emanuele Camerucci, MD (Kansas University Medical Center)	Dr. Camerucci has nothing to disclose.
James H. Bower, MD, MSc, FAAN (Mayo Clinic)	The institution of Dr. Bower has received research support from Abbvie.
Rodolfo Savica, MD, PhD, FAAN (Mayo Clinic)	The institution of Dr. Savica has received research support from ACADIA Pharmaceuticals, Inc.

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