This study analyzed mortality rate patterns related to hypertension and Parkinson's disease across different demographics in the United States.

The CDC-WONDER database was used to extract data on hypertension-related Parkinson's disease mortality among individuals aged 65 and above from 1999-2020. Death certificate data included MCD-ICD 10 codes G20 and G21 for Parkinson's and I10 to I15 for hypertension. Age-adjusted mortality rates (AAMRs) per 100,000 and annual percentage change (APC) were calculated by gender, race/ethnicity, census region, and urbanization level.

Between 1999 and 2020, there were 131,415 hypertension-associated Parkinson's-related deaths among individuals aged 65 and older. The age-adjusted mortality rate (AAMR) rose from 5.71 in 1999 to 11.41 in 2001 (APC: 33.96, 95% CI: 12.53, 50.66), increasing further to 17.12 in 2018 (APC: 1.56, 95% CI: 0.66, 2.13). A sharp rise occurred in 2020, reaching 24.26 (APC: 22.10, 95% CI: 11.78, 28.69). Throughout the period, males had consistently higher AAMRs than females, rising from 7.36 in 1999 to 34.58 in 2020, compared to an increase from 4.80 to 16.80 in females. The highest overall AAMRs were seen in non-Hispanic white (25.3) and Hispanic or Latino populations (25), followed by non-Hispanic Asian or Pacific Islander (19) and non-Hispanic Black or African American (17). AAMRs were higher in non-metropolitan areas (27.5) than in metropolitan areas (23.5), with the South having the highest regional AAMR (26.96), followed by the West (24.36).