To analyze the demographic trends in mortality rates due to ischemic heart diseases (IHD) in individuals with Parkinson’s disease (PD) in the United States from 1999 to 2020.

PD is associated with an increased risk of cardiovascular comorbidities, including IHD, particularly in older adults. Understanding mortality trends in PD patients with IHD is crucial for developing targeted interventions to reduce cardiovascular-related deaths in this vulnerable population.

Mortality data from 1999 to 2020 were extracted from the CDC WONDER database, using ICD-10 codes G20 for PD and I20-I25 for IHD. Age-adjusted mortality rates (AAMR) per 100,000 were calculated for individuals aged 65 years and older, and trends were analyzed based on gender, year, race, region, and state. Annual percentage change (APC) with 95% confidence intervals (CI) was computed using joinpoint regression.

Our analysis reveals a general decrease in deaths due to IHD among individuals with PD. However, the recent increase in mortality rates from 2018 to 2020 warrants further investigation. The findings highlight gender, racial, and regional disparities that may necessitate targeted interventions to alleviate cardiovascular risks in the PD population.