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Abstract Details

Long-Term Surgical Outcome and Its Predictors After Hemispherotomy for Drug-Resistant Epilepsy – a Lower-Middle-Income Country Perspective!
Epilepsy/Clinical Neurophysiology (EEG)
P2 - Poster Session 2 (8:00 AM-9:00 AM)
9-012
We aimed to determine the surgical outcome and its predictors in patients undergoing hemispherotomy for drug-resistant epilepsy and compare the outcome between the pediatric age group and above
Hemispherotomy is an effective surgical approach for drug-resistant epilepsy with hemispheric epileptogenic lesions. 
This is a single-center retrospective study. We assessed the relationship between the post-surgical outcome and clinical, demographic, EEG, and MRI brain characteristics using logistic regression. Also, classified patients according to their age, duration of epilepsy and assessed each patient's postoperative seizure outcome

150 patients, mean age at surgery 11.21 + 6.39 years, mean duration of seizures at time of referral 5.88 + 5.34 years and at surgery 7.86 + 6.15. 89 patients (59.3%) were of age less than 12 years (pediatric group). Most common pathology was Porencephalic cyst (33 patients, 30%), and MRI showed contralateral pathology in 15 patients (10%). EEG showed lateralized IEDs in 59 patients (39.3%) and ipsilateral ictal onset in 66 patients(44%). 71.3% were seizure-free and 78% had Engel class I outcome at last follow-up with mean follow-up of 8.42 years. Acute postoperative seizures (APOS), (OR 3.08; CI 1.23-7.69; p-value:0.016), and contralateral slowing in post-operative EEG at 1 year (OR 7.64; CI 3.25- 17.97; p-value:0.000) were independently predictive of poor seizure outcome. In survival analysis, the probability of seizure freedom was comparable between pediatric age and above, however, it was significantly higher in patients with epilepsy duration < 5 years (70% vs 50%; p value 0.047).

The presence of APOS and contralateral slowing in post-operative EEG are key determinants of poor seizure outcomes. There is no difference in seizure outcome with regard to age at surgery, however, those with shorter epilepsy duration had a better outcome.  This emphasizes the need to bridge the surgical treatment gap by ensuring prompt referrals and addressing obstacles preventing epilepsy surgery
Authors/Disclosures
Nandana Jayakumari, MD, DM
PRESENTER
Dr. Jayakumari has nothing to disclose.
Manisha Karamala Yalapalli, Sr., MD (Sree Chitra Tirunal Institute) Dr. Karamala Yalapalli has nothing to disclose.
Ramshekhar N. Menon, MD, MBBS, DM; PDF (Neurology Dept, Sree Chitra Tirunal Institute for Medical Sciences & Technology) Dr. MENON has nothing to disclose.
Ashalatha Radhakrishnan, Sr., MD (Sree Chitra Tirunal Institute for Medical Sciences & Technology) Dr. Radhakrishnan has nothing to disclose.