Abstract Details

Title Temporal and Regional Trends of Cardiovascular Mortality in Parkinson's Disease Patients in the US: A Retrospective Study from 1999 to 2020

Topic Movement Disorders

Presentation(s) P2 - Poster Session 2 (8:00 AM-9:00 AM)

Poster/Presentation
Number 5-013

Objective We aim to identify cardiovascular mortality trends in patients with Parkinson’s disease (PD) in the US stratified by age, sex, race, and region, and compare them to cardiovascular mortality trends in the general population.

Background PD is a common neurodegenerative disorder, and existing evidence links it to cardiovascular mortality.

Design/Methods Death certificates from the CDC-WONDER database were examined for adults aged ≥65 years. Crude rates (CMR) and age-adjusted mortality rates (AAMRs) per 100,000 persons were calculated, and change in AAMR was determined via annual percent change (APC) and the average APC (AAPC) using Joinpoint regression.

Results From 1999 to 2020, a total of 138,151 cardiovascular deaths occurred in individuals with PD. The AAMRs decreased moderately till 2002 (APC: -3.25), then sharply till 2014 (APC: -5.43), but increased thereafter till 2020 (APC: 1.77). Males had higher AAMR than females, and the AAPC differed significantly from the general population. Non-Hispanic (NH) Whites displayed the highest AAMR (16.14) while NH Blacks or African Americans displayed the lowest (9.65). AAMRs also varied substantially by region (West: 16.64; Midwest: 16.40; Northeast: 15.59; South: 13.12). Rural regions exhibited a higher AAMR (16.34) than Urban regions (14.88). The AAPC for cardiovascular deaths in PD differed significantly from those in the general population in the West and in urban regions. Most deaths occurred at nursing homes or long-term care (43.85%). The adults aged ≥85 years exhibited an alarmingly high CMR (53.04), and the AAPC differed significantly from the general population.

Conclusions We observed overall decreasing trends in cardiovascular deaths in adults with PD from 1999 to 2014, which increased thereafter till 2020. Highest mortality was exhibited by males and NH Whites, residents of the West and urban areas, and older adults. Focused policies should be implemented to reduce cardiovascular mortality in adults with PD in these high-risk populations.

Authors/Disclosures
Hamza Jamil, MD PRESENTER	Dr. Jamil has nothing to disclose.
Zain A. Nadeem (Allama Iqbal Medical College)	Mr. Nadeem has nothing to disclose.
Obaid Ur Rehman	Mr. Rehman has nothing to disclose.
Eeman Ahmad	Eeman Ahmad has nothing to disclose.
Muhammad Bilal Sardar	Dr. Sardar has nothing to disclose.
Aimen Nadeem	Miss Nadeem has nothing to disclose.
Syed H. Inam, MD	Dr. Inam has nothing to disclose.
Sheharyar Raashid, MD	Sheharyar Raashid, MD has nothing to disclose.
Justin M. Nolte, MD	Dr. Nolte has nothing to disclose.

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