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Abstract Details

Modeling the Prodromal Phase of Parkinson's Disease in the Paraquat and Lectin Rat Model
Movement Disorders
P2 - Poster Session 2 (8:00 AM-9:00 AM)
5-015
To develop a rodent model of Parkinson’s disease which recapitulates REM sleep behavior disorder-like sleep abnormalities, a highly specific risk factor and component of the prodromal phase of Parkinson’s disease. 
REM sleep is a phase of sleep characterized by rapid eye movement and atonia. REM sleep behavior disorder (RBD) is a clinical condition in humans where atonia is lost during REM sleep, and dream enactment often occurs. RBD represents an important and specific risk factor for the development of Lewy body diseases, such as Parkinson’s disease or Dementia with Lewy bodies. The development of an animal model which recapitulates RBD-like sleep abnormalities prior to the onset of motor deficits is critical for understanding the prodromal phase, and for future research investigating slowing the progression of Parkinson’s disease. 
Video polysomnography (vPSG) was used to investigate RBD-like sleep abnormalities in a rat model of Parkinson’s disease in which subthreshold doses of the herbicide paraquat and dietary lectins are orally administered for 90 days. Headcaps were implanted for 24 hour sleep wake recordings of EOG, EEG, and EMG. Analysis of vPSG and motor behaviors were taken every two weeks to capture the progression of sleep abnormalities in relation to motor deficits. 
Rats show RBD-like sleep abnormalities, characterized by REM sleep without atonia, as early as two weeks following initiation of paraquat and lectin treatment, prior to the onset of motor deficits. 
The paraquat and lectin rat model holds strong face and construct validity as a model for Parkinson’s disease, recapitulating non-motor aspects of the prodromal phase followed by a steady progression of motor deficits. 
Authors/Disclosures
Caroline C. Swain, MS
PRESENTER 		Miss Swain has nothing to disclose.
Khoi Le Khoi Le has nothing to disclose.
Vaibhavi V. Peshattiwar, PhD Dr. Peshattiwar has nothing to disclose.
Dipesh Pokharel, PhD Mr. Pokharel has nothing to disclose.
Kala Venkiteswaran, PhD An immediate family member of Dr. Venkiteswaran has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Neurocrine. An immediate family member of Dr. Venkiteswaran has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Supernus. An immediate family member of Dr. Venkiteswaran has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Teva. The institution of an immediate family member of Dr. Venkiteswaran has received research support from National institutes of health . The institution of an immediate family member of Dr. Venkiteswaran has received research support from Ann and Philip Gladfetler III foundation . An immediate family member of Dr. Venkiteswaran has received publishing royalties from a publication relating to health care. An immediate family member of Dr. Venkiteswaran has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with National institutes of health .
Thyagarajan Subramanian, MD, MBBS, FAAN (University of Toledo) Dr. Subramanian has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Neurocrine. Dr. Subramanian has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Supernus. Dr. Subramanian has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Teva. The institution of Dr. Subramanian has received research support from National Institutes of Health. The institution of Dr. Subramanian has received research support from Ann and Phillip Gladfetler III Foundation. The institution of Dr. Subramanian has received research support from Department of Defense . Dr. Subramanian has received publishing royalties from a publication relating to health care. Dr. Subramanian has received personal compensation in the range of $500-$4,999 for serving as a Grant Reviewer with National Institutes of Health.