Abstract Details

Title Correlation of Psychiatric Manifestations with Clinical Characteristics and Treatment Outcomes in Neurosarcoidosis

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P2 - Poster Session 2 (8:00 AM-9:00 AM)

Poster/Presentation
Number 3-019

Objective To identify associations between psychiatric symptoms and health outcomes in neurosarcoidosis (NS) patients

Background

The relationship between psychiatric symptoms and health outcomes in NS is underexplored. Current literature highlights instances of psychosis, along with the prevalence of mood disorders in general sarcoidosis.

Design/Methods We conducted a chart review of patients with definite or probable NS in greater Houston between 2010-2023. We compared the presence of psychiatric symptoms at initial presentation with those that occurred during the disease course to assess correlations with clinical characteristic and treatment outcomes. Analyses performed using IBM SPSS.

Results Of the (n=55) patients identified to have NS, 21 (38.1%) had psychiatric symptoms at initial presentation, including but not limited to depression, anxiety, psychosis, and mood disorders. A larger proportion, 27 (49.1%) experienced psychiatric symptoms at some point during their disease course. PHQ9 scores after initiation of treatment indicated that 39 patients (70.9%) had none to minimal depression, 11 (20%) with mild to moderate depression, and 5 (9.1%) with moderate to severe depression. Those with initial psychiatric symptoms had higher CSF WBC (p = 0.019), rates of infections (p < .001), number of hospitalizations (p = 0.013), and rates of malignancy (p = 0.028). Those with psychiatric symptoms during their disease course were also found to have higher rates of chronic infection (p = 0.011) and number of hospitalizations (p = 0.009). Higher PHQ9 scores correlated with greater total number of psychiatric symptoms during the disease course (p = 0.003).

Conclusions CSF WBC, malignancy, chronic infections, and hospitalizations positively correlated with NS psychiatric symptoms. Chronic infections and elevated CSF WBC cytokines could disrupt serotonin metabolism, while higher hospitalization and malignancy rates may exacerbate stress or alter neural circuits. Further investigation is needed to understand these correlations and their external validity.

Authors/Disclosures
Tala Al Shawa PRESENTER	Miss Al Shawa has nothing to disclose.
Laya Rao (Villas at Hermann Park)	Ms. Rao has nothing to disclose.
John A. Lincoln, MD, PhD (McGovern Medical School, UTHealth)	The institution of Dr. Lincoln has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi-Genzyme. Dr. Lincoln has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. The institution of Dr. Lincoln has received research support from Deaprtment of Defense. The institution of Dr. Lincoln has received research support from National Institutes of Health. The institution of Dr. Lincoln has received research support from EMD-Serono. Dr. Lincoln has received intellectual property interests from a discovery or technology relating to health care.
John W. Lindsey, MD (University of Texas Health Science Center At Houston)	Dr. Lindsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Lindsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Banner Life Sciences. Dr. Lindsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for TG Therapeutics. Dr. Lindsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mapi. Dr. Lindsey has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Teva. The institution of Dr. Lindsey has received research support from Genentech.
Shaurya Aggarwal	Mr. Aggarwal has nothing to disclose.
Sienna Wu	Ms. Wu has nothing to disclose.
Megan J. Hatcher, BSEd	Ms. Hatcher has nothing to disclose.
Ivy Zheng, BSA	Miss Zheng has nothing to disclose.
Rajesh K. Gupta, MBBS (UTHealth)	Dr. Gupta has nothing to disclose.

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