Abstract Details

Title Connecting Cortical and Subcortical Oscillatory Activity in Patients with Parkinson’s Disease and Dystonia

Topic Movement Disorders

Presentation(s) P3 - Poster Session 3 (11:45 AM-12:45 PM)

Poster/Presentation
Number 5-002

Objective To determine correlations between subcortical and cortical oscillatory activity and dystonia or Parkinson’s Disease (PD) severity in patients undergoing Globus Pallidus internus (GPi) Deep Brain Stimulation (DBS) therapy.

Background The cortico-basal ganglia-thalamic-cortico (CBGTC) motor circuit is likely implicated in both dystonia and PD. DBS targeting the GPi is a surgical treatment for both conditions. Previous studies demonstrate that GPi Local Field Potentials (LFPs) recorded from patients showed beta (20-30 Hz) oscillatory activity desynchronized prior to movement and then re-emerged. However, oscillatory activity has not been evaluated over time or correlated with symptom severity.

Design/Methods GPi LFPs were recorded using the Percept^TM PC DBS device along with EEG across 3-5 research visits for 10 subjects (mean age= 56.7 years) with dystonia and/or PD. Subjects performed 3 one-minute trials each of rest, right finger taps, or left finger taps. Custom MATLAB code used a Fast Fourier Transform to calculate power spectral density (PSD) plots. The area under the curve for selected frequencies was determined for the right/left GPi and sensorimotor cortex, then compared with symptom severity scores.

Results Beta power differed between movement and rest trials. At baseline, beta power decreased with movement compared to rest in 80% of participants. GPi and sensorimotor cortex beta activity strongly correlated at baseline (left hemisphere r(10)=0.8, p=0.3). With subsequent visits, GPi beta power progressively decreased in 5/10 participants, particularly for subjects with dystonia secondary to PD. Similarly, cortical theta activity progressively decreased with DBS therapy. While PD severity had a positive trend with beta oscillatory activity across visits, only baseline visits demonstrated significant correlation with dystonia severity.

Conclusions Differences in beta power during movement and rest correlate with dystonia and Parkinson’s disease symptoms during DBS therapy. The correlation between GPi and sensorimotor cortex beta oscillatory activity suggests measurable downstream effects of GPi DBS in the CBGTC motor circuit.

Authors/Disclosures
Archita Amudhan, Medical Student PRESENTER	Ms. Amudhan has nothing to disclose.
Abigail Alpers	The institution of Ms. Alpers has received research support from NINDS/NIMH.
Richard L. Barbano, MD, PhD, FAAN	Dr. Barbano has received personal compensation for serving as an employee of State of New York/Office of Mental Health. Dr. Barbano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie/Allergan. Dr. Barbano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for 2nd MD. Dr. Barbano has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Allergan/Abbvie. Dr. Barbano has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Visual Dx. Dr. Barbano has received personal compensation in the range of $100,000-$499,999 for serving as an Expert Witness for R L Barbano, MD,PhD, PLLC. The institution of Dr. Barbano has received research support from Fox Foundation. The institution of Dr. Barbano has received research support from Dystonia Study Coalition. The institution of Dr. Barbano has received research support from Revance. Dr. Barbano has received intellectual property interests from a discovery or technology relating to health care.
Caleb Obregon, Medical Student	Mr. Obregon has nothing to disclose.
David L. Sell, DO (University of Rochester)	Dr. Sell has nothing to disclose.
Angela Hewitt, MD, PhD (University of Rochester Medical Center)	Dr. Hewitt has nothing to disclose.

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