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Abstract Details

Overnight Change in Nfl is Related to Sleep Quality in Parkinson’s Disease
Movement Disorders
P3 - Poster Session 3 (11:45 AM-12:45 PM)
5-005

Evaluate the relationship between sleep and overnight changes in neurofilament light chain (NfL) in individuals with Parkinson’s disease (PD) compared to healthy controls (HC).

NfL may have utility as a biomarker of neurodegeneration in PD.1,2 The glymphatic system, which is most active during sleep, clears NfL from the brain.3 Sleep disturbances in PD likely contribute to disease progression,4-9 but the relationship between NfL levels and sleep in PD has not been characterized.

PD participants and HC aged 50-80y underwent an overnight polysomnogram with blood draws at 8:00pm (PM) and 6:00am (AM). Plasma NfL concentration was estimated in pg/mL using Meso Scale Discovery R-plex assays. T-tests were used to compare PM vs AM NfL levels and differences in changes between groups. Correlations were tested with Pearson coefficients. Significance was defined as p<0.05.

 
Forty PD participants (22M/19F, 67.3±5.6y) and 15 HC (6M/9F, 63.5±8.2y) were enrolled. PD participants had reduced sleep efficiency (66.9±15.9% vs 76.5±12.8%; p=0.041) and increased wake after sleep onset (WASO, 114.0±59.1 minutes vs 73.6±51.5 minutes; p=0.023) compared to HC. There was an 8% increase in NfL from PM to AM in PD (PM: 76.2.9±54.5, AM: 81.9±59.3; p=0.037) while no increase was seen in HC (p=0.996). In PD, %change in NfL was negatively correlated with total sleep time (r=-0.50, p=0.002), sleep efficiency (r=-0.47, p=0.003), and time in NREM and REM (r=-0.39, p=0.003 and r=-0.33, p=0.046respectively), and positively with WASO (r=0.52, p=0.001). In HC, %change in NfL was negatively correlated with time in NREM (r=-0.58, p=0.027).
 
Impaired sleep in PD is associated with overnight increases in plasma Nfl, suggesting that changes in plasma NfL could serve as a biomarker of sleep quality. Further research is needed to determine if disruptions in glymphatic system activity are responsible for the overnight changes in NfL seen in PD.
Authors/Disclosures
Caileigh Dintino, BS
PRESENTER 		Ms. Dintino has stock in Abbvie.
Theresa Swift-Scanlan (Virginia Commonwealth University) The institution of Theresa Swift-Scanlan has received research support from National Institutes of Health. Theresa Swift-Scanlan has received intellectual property interests from a discovery or technology relating to health care.
Unsong Oh, MD (Virginia Commonwealth University School of Medicine) Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Horizon Therapeutics. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech.
Nitai Mukhopadhyay (Virginia Commonwealth University) Nitai Mukhopadhyay has nothing to disclose.
Elizabeth Crump (Virginia Commonwealth University Department of Neurology) No disclosure on file
ronnie hayes, RPSGT Mr. hayes has nothing to disclose.
Erika Shelton Erika Shelton has nothing to disclose.
Samantha K. Holden, MD, MS, FAAN (University of Colorado School of Medicine) The institution of Dr. Holden has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cognition Therapeutics.
Josiane Broussard (Colorado State University) Josiane Broussard has nothing to disclose.
Matthew J. Barrett, MD, FAAN (Virginia Commonwealth University) The institution of Dr. Barrett has received research support from Kyowa Kirin. The institution of Dr. Barrett has received research support from NIH.
Sarah Lageman (Virginia Commonwealth University) Sarah Lageman has received personal compensation in the range of $0-$499 for serving as a Content Validator of online materials with CurePSP.
Brian Berman, MD, MS, FAAN (Virginia Commonwealth University) The institution of Dr. Berman has received research support from Dystonia Medical Research Foundation. The institution of Dr. Berman has received research support from National Institutes of Health. The institution of Dr. Berman has received research support from Neurocrine Biosciences. The institution of Dr. Berman has received research support from Benign Essential Blepharospasm Research Foundation. The institution of Dr. Berman has received research support from National Institutes of Health.