Abstract Details

Title Symmetry of Sleep Spindles Predicts Surgical Outcomes in Corpus Callosotomy

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P3 - Poster Session 3 (11:45 AM-12:45 PM)

Poster/Presentation
Number 9-010

Objective To assess if the symmetry of bilateral sleep spindles can predict surgical outcomes in corpus callosotomy.

Background Corpus callosotomy is a palliative surgical treatment that could be offered to persons with medication-resistant epilepsy that reduces the severity and frequency of generalized seizures by disconnecting the two cerebral hemispheres. To this date pre-surgical predictors of response to corpus callosotomy remain poorly understood.

Design/Methods EEG was obtained using the international 10-20 system from 10 persons with medication-resistant epilepsy prior to their corpus callosotomy as part of routine pre-surgical evaluation. Only the initial 24 hours of EEG was included in the analysis to minimize the confounding effects of medication withdrawal. The EEG was down sampled to 100 Hz, and bandpass filtered (third order Butterworth filter, zero phase shift) to low-frequency sleep spindle (10-12 Hz) and high-frequency sleep spindle (12-16 Hz). The symmetry of sleep spindles was assessed using cross-correlation at 0-time lag for each homologous electrode pairs in the frontal, central, and parietal scalp EEG electrodes. Inter-group differences were assessed using 2-tailed t-test.

Results The super responders to corpus callosotomy showed a higher cross-correlation in the low-frequency sleep spindles compared to the poor responders in the central area (P = 0.04), but not in the frontal (P = 0.86) or the parietal (P = 0.97) regions. There was no inter-group difference in the high-frequency sleep spindles.

Conclusions The symmetry of the sleep spindles in the pre-surgical scalp EEG may serve as a predictor of post-surgical outcome in corpus callosotomy.

Authors/Disclosures
Joshua Abata, MD (UC Irvine) PRESENTER	Dr. Abata has nothing to disclose.
Mio Jiang	Ms. Jiang has nothing to disclose.
Victoria Ho, MD, PhD (UCLA Neurology)	The institution of Dr. Ho has received research support from NIH.
Sumeet Vadera, MD	Dr. Vadera has nothing to disclose.
Mona Sazgar, MD (University of California, Irvine)	Dr. Sazgar has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eisai. Dr. Sazgar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Xenon. Dr. Sazgar has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for UCB. Dr. Sazgar has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Neurelis. Dr. Sazgar has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Eisai. Dr. Sazgar has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for SK Lifesciences. The institution of Dr. Sazgar has received research support from UCB. Dr. Sazgar has received publishing royalties from a publication relating to health care.
Lilit Mnatsakanyan, MD (UC Irvine Medical Center)	Dr. Mnatsakanyan has nothing to disclose.
Brian Jung, MD	Dr. Jung has nothing to disclose.

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