Abstract Details

Title The Impact of Respiratory Muscle Training on Respiratory Function in Patients with Neuromuscular Diseases: A Systematic Review and Meta-analysis

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P3 - Poster Session 3 (11:45 AM-12:45 PM)

Poster/Presentation
Number 11-026

Objective To evaluate the impact of respiratory physiotherapy, particularly respiratory muscle training (RMT), on patients with neuromuscular diseases (NMDs).

Background NMDs impair respiratory muscle function, increasing morbidity and mortality. RMT is used to manage these complications, but its efficacy across NMDs remains uncertain. This systematic review and meta-analysis assessed the effect of RMT on respiratory muscle function in NMD patients.

Design/Methods A systematic search of databases, including MEDLINE, EMBASE, Web of Science, Cochrane, CRS-Web, PEDro, LILACS, ICTPR, the China National Knowledge Infrastructure database, and ClinicalTrials.gov, was conducted up to September 2023. Randomized controlled trials (RCTs) and cohort studies evaluating RMT’s effect on lung volumes and respiratory muscle strength in NMD patients were included. Risk of bias was evaluated using the Cochrane tool for RCTs and Newcastle-Ottawa Scale for cohorts. Meta-analyses used random-effects models, and heterogeneity was assessed with I² statistics.

Results Seventeen studies from 7669 screened articles were analyzed. Meta-analysis showed significant improvements in respiratory muscle strength, particularly in peak inspiratory static maximum (PISMax) (MD: 2.49 cmH2O, 95% CI: 1.74-3.23, p < 0.0001) and peak esophageal pressure maximum (PESMax) (MD: 2.08 cmH2O, 95% CI: 1.30-2.87, p < 0.0001). Nonsignificant increases were observed in forced vital capacity (FVC%) (MD: 2.07%, 95% CI: -3.01 to 7.14, p = 0.42) and maximal inspiratory pressure (MIP) (MD: 4.72 cmH2O, 95% CI: -2.13 to 11.58, p = 0.17). The review indicated over two-thirds of patients experienced improved respiratory muscle strength with RMT. Heterogeneity was moderate to high in some outcomes (I² > 50%).

Conclusions RMT improves respiratory muscle strength in NMD patients. However, variability in study designs and populations limits statistical significance in some parameters. Future studies should standardize interventions and outcomes to better evaluate RMT efficacy.

Authors/Disclosures
Angie C. Alonso, MD PRESENTER	Miss Alonso has nothing to disclose.
Nancy Yesenia Ortiz-Garcia, MD	Dr. Ortiz-Garcia has nothing to disclose.
Diego Rueda, MBBS	Mr. Rueda has nothing to disclose.
Ajay Kumar, MBBS	Dr. Kumar has nothing to disclose.
Domenica Herrera, MD	Dr. Herrera has nothing to disclose.
Diana Othon, MD	Dr. Othon has nothing to disclose.
Jonathan Reyes-Rivera (Universidad Autonoma de San Luis Potosi)	Mr. Reyes-Rivera has nothing to disclose.
Frances M. Mejia, MD	Miss Mejia has nothing to disclose.
Jonathan Martinez Illan, MD	Dr. Martinez Illan has nothing to disclose.
Elda J. Pérez Moreno	Miss Pérez Moreno has nothing to disclose.
Camila Sanchez Cruz	Dr. Sanchez Cruz has nothing to disclose.
Ernesto Calderon Martinez, MD	Dr. Calderon Martinez has nothing to disclose.

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