好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Higher Atrial Fibrillation Probability and Delta Age Computed by Artificial Intelligence-ECG Models Predict More Cardiovascular Events in Patients with Migraine
Headache
P4 - Poster Session 4 (5:00 PM-6:00 PM)
12-001

To investigate the predictive ability of artificial intelligence (AI)-electrocardiogram (ECG) models on adverse vascular events in patients with migraine.
Migraine, especially migraine with aura, is associated with an increased risk of cardiovascular events. Our institution has developed AI-ECG models that could estimate the probability of atrial fibrillation (AF) and patients’ age from normal sinus rhythm (NSR) ECG, and delta age (estimated age – actual age) has also been shown to reflect cardiovascular health.

Adult patients with migraine who had at least one digital, standard 12-lead ECG from 2000 to 2020 were identified. The first NSR ECG was defined as the index ECG. Those with adverse vascular events of interest or AF prior to or within 3 days after index ECG were excluded. The vascular events of interest included acute myocardial infarction, acute ischemic stroke, venous thromboembolism and death. AI-ECG models were implemented to estimate AF probability and delta age from index ECG.
A total of 29928 patients were included. The mean age was 44.3±14.5 years and the median follow-up time was 54 months. Multivariate Cox regression model demonstrated that a higher estimated AF prediction model output was associated with a higher risk of composite vascular outcomes (HR: 1.15 [95% CI: 1.12–1.18] for every 10% increase) after adjustment with age, sex, presence of aura and vascular risk factors. The same was also true for delta age (HR: 1.16 [1.12–1.21] for every 10-year increase). Moreover, an estimated AF probability of ≥1% (HR: 1.45 [1.36–1.54]) and delta age ≥-1 years (HR: 1.09 [1.02–1.16]) were found to be the optimal cutoffs to dichotomize patients into high- and low-risk groups.
AI-ECG AF prediction model output and delta age could potentially be used to identify migraine patients at risk for adverse vascular outcomes.
Authors/Disclosures
Ping-Hao Yang, MD
PRESENTER 		Dr. Yang has nothing to disclose.
Nan Zhang Nan Zhang has nothing to disclose.
Chieh-Ju Chao No disclosure on file
Francisco Lopez-Jimenez, MD The institution of Dr. Lopez-Jimenez has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Anumana. Dr. Lopez-Jimenez has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novo Nordisk. Dr. Lopez-Jimenez has stock in Colibri . The institution of Dr. Lopez-Jimenez has received research support from Anumana. Dr. Lopez-Jimenez has received intellectual property interests from a discovery or technology relating to health care. Dr. Lopez-Jimenez has received publishing royalties from a publication relating to health care.
Kathryn Mangold, PhD Dr. Mangold has received intellectual property interests from a discovery or technology relating to health care.
Zachi Attia Zachi Attia has received personal compensation in the range of $0-$499 for serving as a Consultant for Anumana. Zachi Attia has received personal compensation in the range of $0-$499 for serving as a Consultant for XAI. Zachi Attia has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Pfizer.
Paul Friedman Paul Friedman has received intellectual property interests from a discovery or technology relating to health care. Paul Friedman has received intellectual property interests from a discovery or technology relating to health care. Paul Friedman has received intellectual property interests from a discovery or technology relating to health care.
Peter Noseworthy Peter Noseworthy has nothing to disclose.
Chia-Chun Chiang, MD (Mayo Clinic) Dr. Chiang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Satsuma. Dr. Chiang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Aruene Corporation . Dr. Chiang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pfizer. Dr. Chiang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AbbVie. Dr. Chiang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. The institution of Dr. Chiang has received research support from American Heart Association. The institution of Dr. Chiang has received research support from Lundbeck. The institution of Dr. Chiang has received research support from Pfizer.