Abstract Details

Title The Role of Neutrophil to Lymphocyte Ratio in Prognosis of Spinal Cord Injury: A Systematic Review and Meta-analysis

Topic Neuro Trauma and Critical Care

Presentation(s) P4 - Poster Session 4 (5:00 PM-6:00 PM)

Poster/Presentation
Number 4-002

Objective We aimed to evaluate the prognostic value of Neutrophil-to-lymphocyte ratio in Spinal cord injury patients.

Background Spinal cord injury (SCI) is a debilitating condition linked to long-term morbidity and significant
quality-of-life impacts. Accurate prognostication for SCI patients is crucial for informing
treatment strategies, managing expectations, and enhancing outcomes. The neutrophil-to-
lymphocyte ratio (NLR) shows potential as a reliable prognostic marker for SCI, necessitating
further research to confirm its clinical utility and routine application.

Design/Methods We conducted a thorough search of electronic databases, including PubMed, Europe PMC,
Science Direct, and Google Scholar, using relevant keywords such as neutrophil-to-lymphocyte
ratio, spinal cord injury, prognosis, and outcome along with Boolean operators. Our selection included studies related to SCI and NLR, emphasizing outcomes like
functional recovery, ASIA scores, neurological improvement, and long-term survival, while
excluding case reports, reviews, commentaries, editorials, and animal studies.

Results Three studies with a total of 997 patients met the inclusion criteria. Our study found that a higher
NLR was associated with worse prognosis (MD = 10.36, 95% CI [2.01, 18.72], p = 0.02, I² =
97%). The odds ratio (OR) was 0.83 (95% CI [0.63, 1.09], p = 0.18, I² = 80%). The AUC value
indicated good discrimination ability (AUC = 0.83, 95% CI [0.70 to 0.97], p < 0.01, I² = 98%),
though high heterogeneity may complicate interpretation.

Conclusions Higher NLR values are associated with worse outcomes. Significant heterogeneity and limited
findings from current studies may complicate interpretation. Future research should prioritize
larger studies with wider coverage.

Authors/Disclosures
Saurabh Kataria, MD (Pier Landing) PRESENTER	Dr. Kataria has nothing to disclose.
Alexander Erick Purnomo (University of Pelita Harapan, Karawaci, Tangerang, Banten, Indonesia)	No disclosure on file
Utsav Patel	Utsav Patel has nothing to disclose.
Alexander Erick Purnomo (University of Pelita Harapan, Karawaci, Tangerang, Banten, Indonesia)	No disclosure on file
Prakriti Arya, MBBS	Dr. Arya has nothing to disclose.
Sanidhya Karve, MD	Dr. Karve has nothing to disclose.
Alexander Erick Purnomo (University of Pelita Harapan, Karawaci, Tangerang, Banten, Indonesia)	No disclosure on file
Shakunt H. Sarvaiya, MBBS	Dr. Sarvaiya has nothing to disclose.
Alan Kaye (LSUHSC Sghreveport)	Alan Kaye has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Heliyon Journal. Alan Kaye has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Pain Physician Journal. Alan Kaye has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Current Pain and Headache Reports.

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