Ketosis achieved through a ketogenic diet has been shown to have neuroprotective, anti-inflammatory, antiepileptic, and anti-neoplastic properties. The ketogenic diet requires a limited intake of carbohydrate rich foods and/or intermittent fasting periods; it is difficult for most patients to maintain prolonged ketosis. KME supplementation may overcome some difficulties with adherence and may support the health benefits of ketosis.

Four healthy and 2 IDH-mutant glioma participants (1 astrocytoma; 1 oligodendroglioma) were enrolled. We acquired data on a 7T Philips MRI before and after ingestion of 1 dose deltaG Tactical (KME). Single-voxel sLASER data were acquired from the posterior cingulate cortex in heathy, and the T₂-FLAIR-hyperintense regions in patients. Data acquisition was performed before ingestion (1 measurement), immediately after ingestion (6 consecutive measurements), and after an idle period (6 consecutive measurements). Data were quantified using Osprey and LCModel linear-combination modeling software. Levels of bHB were normalized to the internal concentration reference total creatine (bHB/tCr). Blood ketone measurements were taken before KME ingestion and following the second and third MRS session.

Exogeneous KME supplementation raises the level of bHB above the threshold of detectability on MRS in normal-appearing brain as well as IDH-mutant glioma with peak reached approximately 1 hour after ingestion.