Abstract Details

Title Enlarged Perivascular Spaces Among Hispanic/Latino Adults in SOL-INCA-MRI

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P4 - Poster Session 4 (5:00 PM-6:00 PM)

Poster/Presentation
Number 3-004

Objective To examine the associations between enlarged perivascular spaces (ePVS) and cerebrovascular small vessel disease, cortical atrophy, and cognitive impairment in Hispanic/Latino adults.

Background The Hispanic/Latino population faces higher prevalences of dementia and vascular disease, but is underrepresented in dementia research. This study addresses this gap by investigating ePVS in a large Hispanic/Latino cohort.

Design/Methods Brain MRIs from 2,668 participants in the SOL-INCA-MRI study were analyzed. ePVS volume was quantified using an automated method, and then mean ePVS volumes were residualized with total cerebral volume. Associations between residualized mean ePVS volumes and demographic factors, MRI measures, and cognitive impairment were assessed using regression models.

Results Residualized mean ePVS volume was significantly associated with age (p < 0.001) and varied by Hispanic/Latino heritage. After adjusting for age, sex, and heritage, ePVS volume was associated with MRI infarction (p = 0.01), white matter hyperintensity volume (p < 0.003), presence of cerebral microbleeds (p = 0.004), and cortical gray matter and hippocampal atrophy. Cognitively impaired participants also had significantly larger ePVS volumes (0.21 ± 0.069, p = 0.002). No significant sex differences in ePVS volume were observed when adjusting for head size. Significant differences by heritage were also found, with mean ePVS volume largest among Cuban and smallest among Dominican participants.

Conclusions This study, the largest of ePVS in the Hispanic/Latino population to date, demonstrates significant associations between ePVS volume and established markers of cerebrovascular small vessel disease, cortical atrophy, and cognitive impairment. These findings help fill a large research gap in understanding the etiology of neurocognitive degeneration in Hispanic/Latino adults, and they suggest that ePVS may be a relevant marker of brain health in this population.

Authors/Disclosures
Tuyet Thao Nguyen PRESENTER	Ms. Nguyen has nothing to disclose.
Baljeet Singh	Mr. Singh has nothing to disclose.
Daniel L. Schwartz, BA	Mr. Schwartz has received intellectual property interests from a discovery or technology relating to health care.
Lisa Silbert, MD, FAAN (OHSU)	The institution of Dr. Silbert has received research support from the NIH. Dr. Silbert has received personal compensation in the range of $0-$499 for serving as a Peer Reviewer, study section with NIH.
Carmen Isasi	The institution of Carmen Isasi has received research support from NIH.
Fernando D. Testai, MD, PhD, FAAN (University of Illinois at Chicago)	Dr. Testai has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Testai has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Livingston, Barger, Brandt & Schroeder, L.L.P.. Dr. Testai has received publishing royalties from a publication relating to health care.
Linda Gallo	Linda Gallo has nothing to disclose.
Gregory Talavera (San Diego State University)	Gregory Talavera has nothing to disclose.
Hector Gonzalez	Hector Gonzalez has nothing to disclose.
Charles S. DeCarli, MD, FAAN (UC Davis Health - Dept of NeurologyAlzheimer's Disease Research Center)	Dr. DeCarli has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novo Nordisk. The institution of Dr. DeCarli has received research support from NIH.

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