Abstract Details

Title Brain Perfusion Abnormalities using pCASL Imaging in Participants with Acute Post-Traumatic Headache due to Mild Traumatic Brain Injury

Topic Headache

Presentation(s) P4 - Poster Session 4 (5:00 PM-6:00 PM)

Poster/Presentation
Number 12-005

Objective To investigate cerebral blood flow (CBF) differences between participants with acute post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) and healthy controls (HCs), and CBF correlations with clinical variables.

Background Perfusion abnormalities are shown to occur after TBI, leading to changes in blood flow regulation and oxygen delivery to the brain contributing to the development of PTH.

Design/Methods

Participants with acute PTH due to mTBI were enrolled between date of injury and 59 days post mTBI. CBF was acquired using a 5-delay pseudo continuous arterial spin labelling sequence (pCASL) with 5 averages and a pulse duration of 0.5s, TR=4s, TE= 18.7ms, 3.5mm isotropic resolution with matrix size of 64x64x32. Group CBF differences between PTH participants and HCs were interrogated using two group F-test with p<0.001 and a minimum threshold of 25 voxels corrected for age and sex using SPM12 and MATLABv11. The CBF from regions with significant group differences were extracted using MATLABv11 and a multiple linear regression model corrected for age and sex was used to assess associations with clinical variables including time since mTBI, headache frequency, number of mTBIs, and Sport Concussion Assessment Tool (SCAT) scores.

Results 32 PTH participants with mTBI and 37 HCs were included. Increased CBF was observed in a 0.65 cm³ cluster centered in the right inferior temporal lobe and extending into the right fusiform gyrus and right temporal pole in PTH participants. No areas of decreased CBF were detected in PTH participants compared to HCs. In PTH participants, a negative association was observed between increased CBF in the right temporal pole (β= -0.22 mL/100g/min /day since mTBI, p=0.007) and days since mTBI.

Conclusions

PTH participants had increased blood flow in the right temporal lobe compared to HCs. There were no correlations with headache severity, headache frequency, or number of mTBIs.

Authors/Disclosures
Simona Nikolova, PhD (Mayo Clinic) PRESENTER	Dr. Nikolova has nothing to disclose.
Todd J. Schwedt, MD, FAAN (Mayo Clinic)	Dr. Schwedt has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lilly. Dr. Schwedt has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lundbeck. Dr. Schwedt has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie. Dr. Schwedt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Linpharma. Dr. Schwedt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Theranica. Dr. Schwedt has received personal compensation in the range of $0-$499 for serving as a Consultant for Amgen. Dr. Schwedt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Scilex. Dr. Schwedt has stock in Aural Analytics. Dr. Schwedt has stock in Nocira. Dr. Schwedt has stock in Allevalux. The institution of Dr. Schwedt has received research support from National Institutes of Health. The institution of Dr. Schwedt has received research support from United States Department of Defense. The institution of Dr. Schwedt has received research support from Patient Centered Outcomes Research Institute. The institution of Dr. Schwedt has received research support from SPARK Neuro. The institution of Dr. Schwedt has received research support from Henry Jackson Foundation. The institution of Dr. Schwedt has received research support from Pfizer. The institution of Dr. Schwedt has received research support from National Headache Foundation. The institution of Dr. Schwedt has received research support from American Heart Association. Dr. Schwedt has received intellectual property interests from a discovery or technology relating to health care. Dr. Schwedt has received intellectual property interests from a discovery or technology relating to health care. Dr. Schwedt has received intellectual property interests from a discovery or technology relating to health care. Dr. Schwedt has received intellectual property interests from a discovery or technology relating to health care. Dr. Schwedt has received publishing royalties from a publication relating to health care.
Gina Dumkrieger, PhD (Mayo Clinic)	Gina Dumkrieger has received personal compensation for serving as an employee of Mayo Clinic. The institution of Gina Dumkrieger has received research support from NIH. The institution of Gina Dumkrieger has received research support from DOD. The institution of Gina Dumkrieger has received research support from AMGEN.
Jing Li (Georgia Institute of Technology)	Jing Li has nothing to disclose.
Aaron Thomas, MD	Dr. Thomas has nothing to disclose.
Teresa Wu (Arizona State University)	Teresa Wu has nothing to disclose.
Katherine Ross (Phoenix VA Health Care System)	Katherine Ross has nothing to disclose.
Yuxiang Zhou, PhD	Dr. Zhou has nothing to disclose.
Dani Smith, MS	Miss Smith has nothing to disclose.
Michael R. Leonard, CCRP	Mr. Leonard has nothing to disclose.
Catherine D. Chong, PhD, FAAN	Dr. Chong has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for HCOP.

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