Abstract Details

Title Magnetic Resonance Fingerprinting for Quantitative Hippocampal Subfield Analysis in Elderly Patients with Epilepsy

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P4 - Poster Session 4 (5:00 PM-6:00 PM)

Poster/Presentation
Number 9-006

Objective To use magnetic resonance fingerprinting (MRF) to identify T1 and T2 tissue property differences in hippocampal subfields of elderly patients with epilepsy.

Background Elderly patients with epilepsy have increased rates of impaired cognition. MRF is a novel imaging modality that allows for fast and quantitative measurement of intrinsic tissue properties on a voxel-by-voxel basis, which can help identify structural biomarkers of impaired cognition. In this study, we demonstrate the utility of high-resolution 3D MRF in identifying structural differences within hippocampal subfields in elderly patients with epilepsy.

Design/Methods Patients 55 years or older with non-lesional focal epilepsy were included. Participants underwent whole-brain 3T-MRF and conventional MRI using a protocol adapted from the Alzheimer’s Disease Neuroimaging Initiative. After reconstruction of raw MRF data, we generated quantitative T1 and T2 relaxometry maps and co-registered them with T1-weighted and T2-weighted conventional MRI images using Advanced Normalization Tools. We then utilized FreeSurfer and the FS60 atlas to segment hippocampal subfields. T1 and T2 relaxation times in each subfield were then calculated. As a pilot study, we compared the T1 and T2 values for the ipsilateral and contralateral hippocampal subfields for each patient.

Results Fifteen patients (mean age 67y, 47% women) with non-lesional conventional MRI were included. Eight patients had unilateral temporal/frontotemporal lobe epilepsy, three had unilateral frontal lobe epilepsy, and four had multifocal bilateral epilepsy. In patients with unilateral frontotemporal/temporal lobe epilepsy, T2 values were higher in the ipsilateral CA3 and presubiculum compared to the contralateral side, with mean percent increases of 10.7±13.6% (p=0.049) and 9.1±5.9% (p=0.002), respectively.

Conclusions MRF can quantitatively discriminate between structural differences in hippocampal subfields in elderly patients with non-lesional temporal lobe epilepsy. In the future, we aim to demonstrate a correlation between subfield differences and cognitive measures, which may help to identify markers of impaired cognition in this patient population.

Authors/Disclosures
Eric Zhou, MD PRESENTER	Dr. Zhou has nothing to disclose.
Ting-Yu Su, MS	Mr. Su has nothing to disclose.
Lisa L. Ferguson	Mrs. Ferguson has nothing to disclose.
Robyn Busch	Robyn Busch has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier Inc.. Robyn Busch has received research support from National Institutes of Health. Robyn Busch has received research support from American Epilepsy Society. Robyn Busch has received research support from Cleveland Clinic. Robyn Busch has received research support from Ohio Department of Higher ��ɫ��. Robyn Busch has received intellectual property interests from a discovery or technology relating to health care.
Carrie McDonald, PhD	Prof. McDonald has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Neurona Therapeutics. The institution of Prof. McDonald has received research support from NIH.
Irene Wang, PhD	Dr. Wang has nothing to disclose.

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