Abstract Details

Title Associations of Diffusion Tensor Imaging (DTI), Diffusion Kurtosis Imaging (DKI), and Standard Model Imaging (SMI) metrics with obstructive sleep apnea severity in cognitively unimpaired subjects

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P4 - Poster Session 4 (5:00 PM-6:00 PM)

Poster/Presentation
Number 3-010

Objective Our study aims to comprehensively evaluate the effects of obstructive sleep apnea (OSA) on white matter tracts using diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and standard model imaging (SMI) diffusion metrics in a cognitively normal older adult population.

Background

Obstructive sleep apnea (OSA) is a complex condition characterized by repeated episodes of upper airway collapse during sleep, leading to sleep fragmentation and cognitive impairment. Diffusion magnetic resonance imaging (dMRI) techniques, including DTI, DKI, and SMI, offer complementary insights into white matter microstructure

Design/Methods

150 individuals from a community-based study on sleep, memory, and healthy aging underwent one-night nocturnal polysomnography (NPSG), cognitive assessments, and MRI. OSA measurements included the Apnea-Hypopnea Index (AHI) and sleep characteristics derived from the NPSG. The microstructural properties of white matter tracts (DTI, DKI, and SMI metrics) were estimated after preprocessing dMRI using the DESIGNER pipeline.

Results Adjusted models showed negative associations between AHI severity (AHI3A) and Fractional Anisotropy (FA), Axial Diffusivity (AD), and Radial Kurtosis (RK) in the genu of the corpus callosum (GCC) and cingulum, while showing positive associations with Radial Diffusivity (RD). A subject-matched comparison between participants with and without OSA indicated that the OSA group had smaller FA and AD values. ANOVA comparisons of OSA severity revealed that subjects with severe OSA had significantly decreased FA compared to participants with mild or no OSA. The same comparison also showed increased RD values in the GCC and cingulum.

Conclusions

Our study demonstrates that in individuals with OSA, increasing AHI severity is associated with poorer measures of white matter integrity and organization, as evidenced by reduced FA and AD, and increased RD. Additionally, the regions associated with most of these differences have been linked to memory and executive functions, which have also been previously evaluated as being affected by OSA severity.

Authors/Disclosures
Luisa F. Figueredo, MD PRESENTER	Dr. Figueredo has nothing to disclose.
Jenny Chen	Ms. Chen has nothing to disclose.
naomi gaggi, PhD	The institution of Dr. gaggi has received research support from AASM.
Tovia Jacobs	Mr. Jacobs has nothing to disclose.
Xiao Song	No disclosure on file
Gabriela Silva Albornoz, BS	Ms. Silva Albornoz has nothing to disclose.
Moses Gonzalez	Mr. Gonzalez has nothing to disclose.
Joshua L. Gills, PhD	Dr. Gills has nothing to disclose.
Jaime Ramos-Cejudo (NYU Grossman School of Medicine)	Jaime Ramos-Cejudo has nothing to disclose.
Indu Ayappa, PhD	Dr. Ayappa has received intellectual property interests from a discovery or technology relating to health care.
Korey Kam (Mount Sinai)	No disclosure on file
Anna E. Mullins, PhD	Dr. Mullins has nothing to disclose.
Ankit Parekh (Mount Sinai)	No disclosure on file
Andrew Varga, MD, PhD	Dr. Varga has nothing to disclose.
Omonigho M. Bubu, MD, PhD (NYU Grossman School of Medicine)	Dr. Bubu has nothing to disclose.
Esther Blessing (NYU Grossman School of Medicine)	No disclosure on file
Els Fieremans (NYU Grossman School of Medicine)	No disclosure on file
Ricardo Osorio (NYU Langone Health)	No disclosure on file

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