Abstract Details

Title Perception of Physical Function Differs Between Sexes in Patients with Parkinson’s Disease

Topic Movement Disorders

Presentation(s) P4 - Poster Session 4 (5:00 PM-6:00 PM)

Poster/Presentation
Number 5-014

Objective To examine sex differences in clinical characteristics and patient-reported outcomes (PRO) in Parkinson disease (PD).

Background Patient-reported outcomes (PRO) provide valuable information about disease perception, however few studies have evaluated sex disparities between PRO and clinical exam ratings.

Design/Methods We performed a retrospective analysis utilizing data from two large IRB-approved natural history studies of PD. Independent samples t-test and Mann-Whitney U were used to compare continuous variables, and chi-square and Fisher’s exact test for categorical variables.

Results The study sample consisted of 1590 PD patients from two separate institutions, defined as Cohort 1 (N=433) and Cohort 2 (N=1157), with Male(M)/Female(F) ratios of 1.7. Demographics reported as mean (SD), were similar between sexes, with no significant statistical differences in either cohort. For Cohort 1, Age: (years:) M 65 (8.3), F 64 (9.4), p 0.05, disease duration: M 8.6 (5.4), F 8.8 (5.9), p 0.87. For Cohort 2, Age: M 67.6 (9.9), F 68.3 (9.8), p 0.2, disease duration: M 7.2 (5.7), F 7.9 (6.8), p 0.07. M had a higher motor exam severity score than F. For Cohort 1, MDS-UPDRS Part III: M 27.9 (12.3) vs. F 23.7 (12.2), p <0.001, and for Cohort 2: M 27.7 (12.2) vs. F 23.3 (13.2), p=0.07. However, in both cohorts, PROMIS-29 patient-reported Physical Function was worse in females, Cohort 1: M 47.2 (8.8) vs. F 45.4 (8.8), p=0.020, and Cohort 2: M 44.6 (10.2) vs. F 41.8 (10.0), p=0.0001. Greater anxiety was reported by females in both cohorts, Cohort 1: M 50.2 (9.1), F 52.9 (9.5), p=0.003; Cohort 2: M 50.5(9.5), F 53.5 (9.7), p=0.0001.

Conclusions The divergence between clinician-reported motor scores and patient-reported physical function shows that males perceive better function in the setting of greater disease severity. Greater emotional distress in women may contribute to disparities in perception of function.

Authors/Disclosures
Yasir Yilmaz, MD PRESENTER	Dr. Yilmaz has nothing to disclose.
Kaneez Zahra, MD, MBBS (University of Maryland)	Dr. Zahra has nothing to disclose.
Ann Gruber-Baldini	No disclosure on file
Sunita Shakya (UMB)	Sunita Shakya has nothing to disclose.
Joseph Jankovic, MD, FAAN (Baylor College of Medicine)	Dr. Jankovic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Revance. Dr. Jankovic has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Revance, Allergan. The institution of Dr. Jankovic has received research support from Baylor College of Medicine. Dr. Jankovic has received research support from Abbvie. The institution of Dr. Jankovic has received research support from Abbvie.
Joshua M. Shulman, MD, PhD, FAAN (Duncan Neurological Research Institute)	Dr. Shulman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Helis Medical Foudation. The institution of Dr. Shulman has received research support from National Institutes of Health.
Lisa M. Shulman, MD, FAAN (University of Maryland School of Medicine)	The institution of Dr. Shulman has received research support from NIH. Dr. Shulman has received publishing royalties from a publication relating to health care. Dr. Shulman has received publishing royalties from a publication relating to health care.
Nora Vanegas-Arroyave, MD (Baylor College of Medicine)	The institution of Dr. Vanegas-Arroyave has received research support from National Institutes of Health. The institution of Dr. Vanegas-Arroyave has received research support from MJFF.

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