Low-risk post-IVT AIS patients (NIHSS≤10, BP<180/105, no high-risk stenosis/occlusion, preserved level of consciousness) between 10/2020-4/2024 were included. The HIM protocol was utilized in the ICU until March 2022, thereafter TIM was utilized in the intermediate care unit (IMC). HIM protocol vital sign monitoring and neurochecks occurred q15 minutes for 2 hours, q30 minutes for 6 hours, then q1 hour for 16 hours (72 total assessments); TIM protocol vital sign monitoring and neurochecks occurred q15 minutes for one hour, q1 hour for three hours, q2 hours for 8 hours, then q4 hours for 12 hours (28 total assessments). We examined the frequency TIM patients were transferred to the ICU, ICU length of stay, hospital length of stay, symptomatic intracranial hemorrhage (sICH), and early neurologic deterioration (END [NIHSS increase ≥4]). Statistical testing was performed using chi-squared tests and two sample t-test. 

A post-IVT TIM protocol was feasible and safe in selected post-IVT AIS patients. TIM protocols may conserve healthcare resources and increase ICU bed availability.