Abstract Details

Title Altered CSF Pseudo-diffusivity in Preterm Infants with Intra-Ventricular Hemorrhage

Topic Child Neurology and Developmental Neurology

Presentation(s) P5 - Poster Session 5 (8:00 AM-9:00 AM)

Poster/Presentation
Number 6-001

Objective

To evaluate the alterations in cerebrospinal fluid (CSF) circulation and its physical properties in infants suffering from Intraventricular hemorrhage (IVH).

Background IVH and subsequent post-hemorrhagic hydrocephalus (PHH) represent significant neurological complications in preterm infants. IVH alters the composition of cerebrospinal fluid (CSF), impacting its physical properties and initiating inflammatory and cellular responses that could alter CSF space microstructure and/or CSF hydrodynamics.

Design/Methods Diffusion-weighted MRI at low b-values (low-b dMRI) is sensitive to both the intrinsic diffusivity and effective motility of CSF. Using this method, whole-brain maps of CSF mean pseudo-diffusivity (MΨ) were generated. Region of interest analysis was conducted using the CSF Water Ways (CWW) atlas.

Results The study included 62 preterm infants: 38 without IVH (NL), 16 with grade 1/2 IVH (low-grade IVH), and 8 with grade 3/4 IVH (high-grade IVH). Compared to the NL group, CSF MΨ was significantly decreased in the extra-axial subarachnoid space and supracerebellar cistern in infants with low-grade IVH (p < 0.05). In contrast, infants with high-grade IVH exhibited a significant increase in CSF MΨ in the superior pre-medullary cistern compared to both the low-grade IVH and NL groups (p < 0.05).

Conclusions Decreased MΨ in lower grades of IVH within slow-flow CSF spaces may reflect increased viscosity due to the admixture of blood, which has a higher viscosity than normal CSF. Alternatively, this may indicate secondary microstructural changes in the subarachnoid space, such as scarring or thickening of the arachnoid trabeculae, resulting in increased non-CSF tissue partial volume. In higher grades of IVH, hydrodynamic changes likely predominate, leading to higher MΨ.

Authors/Disclosures
Helia Hosseini, MD PRESENTER	Dr. Hosseini has nothing to disclose.
David Limbrick, Jr., MD, PhD	Dr. Limbrick has received personal compensation for serving as an employee of Rhaeos, Inc.. Dr. Limbrick has stock in Deepsight, Inc.. The institution of Dr. Limbrick has received research support from NIH/NINDS. The institution of Dr. Limbrick has received research support from Department of Defense.
Jennifer Strahle, MD	Dr. Strahle has nothing to disclose.
Barbara Warner, MD	The institution of Dr. Warner has received research support from NIH.
Nicholas Reinhold	Mr. Reinhold has nothing to disclose.
Diego M. Morales, MS	Mr. Morales has nothing to disclose.
Thanda Meehan, RN	Ms. Meehan has nothing to disclose.
Laura Linneman, RN	Mrs. Linneman has nothing to disclose.
Dimitrios Alexopoulos, MS	Mr. Alexopoulos has nothing to disclose.
David Loseille	Mr. Loseille has nothing to disclose.
Caleb D. Gardner	Mr. Gardner has nothing to disclose.
Christopher Smyser, MD (Washington University in St. Louis)	Dr. Smyser has nothing to disclose.
Arash Nazeri, MD	Dr. Nazeri has nothing to disclose.

��ɫ��

��ɫ��