Abstract Details

Title Concerning Rising Trends of Hypoxic Ischemic Encephalopathy among Infants in the United States: 17-year analysis

Topic Child Neurology and Developmental Neurology

Presentation(s) P5 - Poster Session 5 (8:00 AM-9:00 AM)

Poster/Presentation
Number 6-003

Objective

To evaluate the mortality trends of hypoxic-ischemic encephalopathy (HIE) stratified by infant age groups, sex, race, and region among infants in the United States (US) from 2006 to 2022.

Background

Hypoxic-ischemic encephalopathy is one of the most common causes of morbidity and mortality among infants. Their mortality trends have not been examined at the general population level in the United States.

Design/Methods

We analyzed the Centers for Disease Control and Prevention's Wide ranging Online Data for Epidemiologic Research (CDC WONDER)) for death certificates (2006-2022) of infants < 1 year of age, with HIE. Crude rates (CR) per 100,000 and annual percent change (APC) with 95% confidence intervals were calculated through joint-point regression analysis.

Results Between 2006 and 2022, a total of 6,630 deaths attributed to HIE were reported among infants in the US. The crude rate increased from 6.1 in 2006 to 14.8 in 2022 [APC = 5.2* 95% CI: 4.4-6.2], a percentage change of 143%. Males (10.5; APC=4.98* 95% CI: 4.2-5.9) had a higher CR than females (9.6; APC=5.54* 95% CI: 4.5-6.8). Among infant age groups, neonates aged 1-6 days had 8 times the CR as infants aged 28-364 days [<1 day=1.13; 1-6 days= 5.22; 7-27 days= 2.91; 28-364 days= 0.63]. Crude rates varied by race [Non-Hispanic (NH) African Americans=13.5; NH Whites=10.5; and Hispanics=7.4] and region [Midwest=10.7; West=10.3; South=9.9; Northeast=8.9]. States above the 90^th percentile were Iowa, North Dakota, Indiana, Maine, and Utah.

Conclusions

HIE-related mortality has been increasing continuously since 2006, especially among NH Blacks, male infants, and in the 1-6 days age group. Interventions, including skilled birth attendants at delivery, newborn resuscitation training for healthcare personnel, and identification of high-risk groups are necessary to reduce the burden of HIE.

Authors/Disclosures
Syed H. Inam, MD PRESENTER	Dr. Inam has nothing to disclose.
Javeria Javeid	Mrs. Javeid has nothing to disclose.
Wajeeh Hassan, MBBS	Mr. Hassan has nothing to disclose.
Mehmood Akhtar, Medical Student	Mr. Akhtar has nothing to disclose.
Muzamil Akhtar, Medical Student	Mr. Akhtar has nothing to disclose.
Danish A. Ashraf (House no 217 askari 14)	Mr. Ashraf has nothing to disclose.
Muhammad Saim	Mr. Saim has nothing to disclose.
Muhammad Umair, MD	Mr. Umair has nothing to disclose.
Muhammad Shehryar Hussain, MBBS	Dr. Hussain has nothing to disclose.
Momna Nisar, MD	Dr. Nisar has nothing to disclose.
James Issa, Student	Mr. Issa has nothing to disclose.

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