Peripheral neuropathy is a widespread neurological condition characterized by damage to the peripheral nerves, leading to sensory and motor dysfunction that can severely impact quality of life.

A total of 61,414 peripheral neuropathy-related deaths were identified over the study period. Mortality rose by 58%, with the AAMR increasing from 1.2 in 1999 to 1.9 in 2020 (AAPC: 2.4 [95% CI: 1.9, 2.9]). While males had higher AAMRs (1.6) compared to females (1), the rate of increase was more pronounced among females (AAPC: 2.7 [95% CI: 2.2, 3.3]). Older adults (5.25) had an AAMR 17.5 times greater than younger adults (0.3). Non-Hispanic Whites (5.76) exhibited the highest AAMRs, followed by non-Hispanic Blacks (3.2), non-Hispanic American Indians (1.8), and Hispanics (0.67). Non-metropolitan areas had a higher AAMR (1.5) compared to metropolitan areas (1.2). Regionally, the West recorded the highest AAMR (1.5), while the Northeast reported the lowest (0.93). States in the top 90th percentile of AAMRs included Colorado, Oregon, Wyoming, Minnesota, and Nebraska.

The increasing mortality from peripheral neuropathy across diverse populations highlights the urgent need for targeted research and intervention. Addressing these trends is critical to improving outcomes and reducing the burden on affected individuals and communities.