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Abstract Details

Platelet-rich Plasma Versus Steroid Injections for the Treatment of Lumbar Radicular Pain Due to Disc Herniation: A Systematic Review and Meta-analysis
Pain
P5 - Poster Session 5 (8:00 AM-9:00 AM)
7-008
To compare the efficacy of Platelet-Rich Plasma vs. steroid Injections injections for treating lumbar radicular pain caused by disc herniation
Lumbar disc herniation is the most frequent cause of lumbar radicular pain (LRP) in adults between their 30s and 50s. Steroid injections are widely used for LRP but can carry rare, yet serious, complications. Recently, PRP has emerged as a potential alternative, promoting healing and reducing inflammation through the release of growth factors and cytokines. 

Following PRISMA guidelines, we performed a comprehensive literature search across electronic databases to identify relevant studies up to October  2024. The primary outcome was the Visual Analogue Scale (VAS) pain score at 4, 6, 12, and 24 weeks. Secondary outcomes included functional improvement, assessed by the Oswestry Disability Index (ODI) at the same time intervals. Standardized mean difference (SMD) before and after treatment with 95% CIs were used for continuous variables.

Seven studies, including five randomized controlled trials (RCTs), one non-RCT, and one observational study, met the inclusion criteria. The meta-analysis revealed that PRP led to significantly greater improvements in VAS pain scores compared to steroid injections at all follow-up periods, except at 4 weeks, where no significant difference was observed [SMD (95% CI): 4 weeks: 0.42 (-0.32, 1.16), p < 0.27; 6 weeks: -0.81 (-1.60, -0.02), p < 0.05; 12 weeks: -0.74 (-1.40, -0.08), p < 0.03; 24 weeks: -1.00 (-1.88, -0.11), p < 0.03]. No significant differences in ODI were found between the groups, except at 24 weeks, where PRP showed a significant improvement [SMD (95% CI): -0.53 (-0.96, -0.10), p < 0.02].

PRP injections appear safe and provide better pain control and functional outcomes at intermediate and long-term follow-ups compared to steroid injections for LRP caused by disc herniation.
Authors/Disclosures
Rashad G. Mohamed, MBBS
PRESENTER
Dr. Mohamed has nothing to disclose.
Khalid W. Sarhan Mr. Sarhan has nothing to disclose.
Reem Reda Elmahdi, MBBS Dr. Reda Elmahdi has nothing to disclose.
Arwa Jader, MD Dr. Jader has nothing to disclose.
Mahmoud D. Hindawi, MBBS Dr. Hindawi? has nothing to disclose.
Ahmed Negida, MD, PhD (Virginia Commonwealth University) Dr. Negida has nothing to disclose.