好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Relation of Optical Coherence Tomography (OCT) Measures to Volumetric MRI in Pediatric-Onset Multiple Sclerosis (POMS)
Neuro-ophthalmology/Neuro-otology
P5 - Poster Session 5 (8:00 AM-9:00 AM)
11-019

To examine the relation of optical coherence tomography (OCT) measures to MRI brain volumetrics in patients with pediatric-onset multiple sclerosis (POMS).

Whole and regional brain tissue volumes and OCT measures have emerged as important structural markers that reflect impairment and disability in MS.  How these structural measures of the eye and brain relate to each other is unclear in POMS.
This was a retrospective cross-sectional study of OCT and MRI measures in a POMS cohort at a single pediatric MS center.  MRI measures of brain volume that were performed as part of clinical care include overall lesion and black hole volumes and volume percentiles (based on age- and sex-related norms) for whole brain (WB), cortical grey matter (CGM), grey matter (GM), hippocampus, and thalamus. Peripapillary retinal nerve fiber layer (RNFL) thickness and macular volumes were recorded from OCT scans obtained during neuro-ophthalmic consultation.
Among 72 patients (144 eyes), median age at the time of the volumetric MRI scan was 18.8 (range 10.6-27.7) years, with a median disease duration of 3.7 (0.13-16.7) years.  Lower (worse) RNFL thicknesses (median 93.1 microns [53-134]) were associated with reduced volumes of WB (p<0.001), CGM (p<0.001), GM (p<0.001), and thalamus (p=0.03, generalized estimating equation [GEE] models).  RNFL thinning was also associated with greater lesion (p=0.009) and black hole volumes (p=0.003).  Macular volumes were reduced for eyes associated with lower WB (p=0.001) and hippocampal volume (p=0.006). On average, 5 mm reductions in RNFL thickness were associated with decreases in whole brain volume by 12 percentile points and with increases in black hole volume by 12 mm3.

Peripapillary RNFL thinning in POMS may reflect loss in overall brain volume and greater lesion and black hole burden on volumetric MRI.  As such, OCT measures represent useful markers of disease status in addition to demonstrating optic nerve involvement in MS.
Authors/Disclosures
Anna Sosa
PRESENTER 		Anna Sosa has nothing to disclose.
Ruben Jauregui, MD Dr. Jauregui has nothing to disclose.
Ugo Nwigwe Mr. Nwigwe has nothing to disclose.
Kimberly O'Neill, MD Dr. O'Neill has nothing to disclose.
Rachel Kenney Rachel Kenney has received personal compensation for serving as an employee of Optum. Rachel Kenney has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Minton 好色先生 LLC.
Thibo Billiet, PhD Dr. Billiet has received personal compensation for serving as an employee of icometrix.
Lauren B. Krupp, MD, FAAN (NYU Langone Medical Center) Dr. krupp has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. krupp has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Celgene. Dr. krupp has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medscape. Dr. krupp has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EBIX. Dr. krupp has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. krupp has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Hoffman LaRoche. Dr. krupp has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for MMMK. Dr. krupp has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Patrick, Dolan, and Kaufman. Dr. krupp has received intellectual property interests from a discovery or technology relating to health care.
Steven Galetta, MD, FAAN (NYU Langone Medical Center) Dr. Galetta has nothing to disclose.
Laura J. Balcer, MD, MSCE, FAAN (NYU Grossman School of Medicine) An immediate family member of Dr. Balcer has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Children's Hospital of Philadelphia.
Scott Grossman, MD (New York University, Langone Health) Dr. Grossman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acuta Pharmaceuticals.