Abstract Details

Title Rapid Automatized Naming and Retinal Neurodegeneration in Multiple Sclerosis and Neuro-Myelitis Optica Spectrum Disorder

Topic Neuro-ophthalmology/Neuro-otology

Presentation(s) P5 - Poster Session 5 (8:00 AM-9:00 AM)

Poster/Presentation
Number 11-022

Objective To investigate the relationship of cognitive-visual performance, as measured by MULES, and retinal integrity and afferent visual function as quantified by OCT and LCLA, in patients with MS and NMOSD

Background Performance on the Mobile Universal Lexicon Evaluation System (MULES), a rapid automatized naming (RAN) task engaging visual and cognitive network pathways, has demonstrated impairment in neurological conditions such as multiple sclerosis (MS), concussion, Parkinson’s and Alzheimer’s diseases. Optical coherence tomography (OCT) and low-contrast letter acuity (LCLA) have demonstrated changes in retinal structure and visual function in MS and neuro-myelitis optica spectrum disorder (NMOSD).

Design/Methods The MULES test, consisting of 54 color photographs of various objects (fruits, animals, and random objects), OCT and high- and low-contrast letter acuity (LCLA) testing were administered to 54 people with MS, 15 with NMOSD, and 15 healthy controls (HC). People with MS included those with clinically isolated syndrome, relapsing remitting MS (RRMS) and progressive MS. OCT imaging of the peripapillary retinal nerve fiber layer (pRNFL) and the macular ganglion cell + inner plexiform layer (GCIPL) were performed. Average pRNFL and GCIPL thickness between both eyes of participants, as well as inter-eye thickness differences, were calculated.

Results Greater MULES time scores, indicating worse performance, were associated with lower average pRNFL thickness in NMOSD (p=0.004, linear regression accounting for age), lower average GCIPL thickness in NMOSD (p=0.019) and higher inter-eye GCIPL thickness differences in RRMS (p=0.003) and HC (p=0.045). Longer MULES times were also associated with worse binocular high- and low-contrast letter acuity scores in both MS and NMOSD (p<0.05).

Conclusions The MULES test of rapid picture naming enhances visual screening when evaluating patients with MS and NMOSD. Greater degrees of retinal neurodegeneration were associated with worse RAN task performance. Inter-eye GCIPL difference is the best OCT predictor of worse RAN task performance in MS.

Authors/Disclosures
Zaara Islam PRESENTER	Miss Islam has nothing to disclose.
Rachel Kenney	Rachel Kenney has received personal compensation for serving as an employee of Optum. Rachel Kenney has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Minton ��ɫ�� LLC.
Laura J. Balcer, MD, MSCE, FAAN (NYU Grossman School of Medicine)	An immediate family member of Dr. Balcer has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Children's Hospital of Philadelphia.
Steven Galetta, MD, FAAN (NYU Langone Medical Center)	Dr. Galetta has nothing to disclose.
Scott Grossman, MD (New York University, Langone Health)	Dr. Grossman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acuta Pharmaceuticals.
Alani Jack (NYU Langone Department of Neurology)	Ms. Jack has nothing to disclose.
Christina Marini	Ms. Marini has nothing to disclose.

��ɫ����

��ɫ����

��ɫ��

��ɫ��