Abstract Details

Title Hyperbaric Oxygen Therapy (HBOT) for Treating Neurocognitive Deficits in Traumatic Brain Injury Patients: A Systematic Review and Meta-analysis

Topic Neuro-rehabilitation

Presentation(s) P6 - Poster Session 6 (11:45 AM-12:45 PM)

Poster/Presentation
Number 4-001

Objective

We performed a Systematic Review and Meta-Analysis to evaluate the efficacy of Hyperbaric Oxygen Therapy (HBOT) in improving neurocognitive outcomes for Traumatic Brain Injury (TBI) patients.

Background Traumatic brain injury (TBI) is a leading cause of disability worldwide, often resulting in long-term neurocognitive impairments that significantly affect survivors' quality of life. However, despite their clinical significance, effective treatment options for these deficits remain limited.

Design/Methods PubMed, Embase, and Cochrane Central databases were systematically searched to identify studies investigating HBOT for treating neurocognitive deficits in traumatic brain injury patients. The primary outcomes comprised of cognitive function, memory, attention, executive function, information processing speed (IPS), and motor skills. We applied a random effects model and pooled mean differences (MDs), along with 95% confidence intervals (CI) using RevMan 5.4. The RoB 2 tool and the ROBINS-E tool were used to assess the quality of randomized controlled trials and observational studies, respectively.

Results

A total of four studies, comprising 250 patients (mean age = 25 years, 43% female), were included. The results demonstrated that after receiving HBOT, TBI patients showed significantly improved general cognitive scores (MD 7.47; p = 0.003), memory (MD 10.13; p < 0.00001), attention (MD 7.99; p < 0.00001), executive function (MD 7.16; p = 0.002), information processing speed (IPS) (MD 7.48; p = 0.01), and motor skills (MD 5.19; p < 0.00001) compared to baseline. Both RCTs were rated as having a low risk of bias, while the two observational studies had a moderate risk of bias due to confounding and selective reporting.

Conclusions HBOT significantly improves neurocognitive deficits in traumatic brain injury patients compared to baseline. However, larger trials with standardized protocols are needed to establish the optimal therapeutic role of HBOT in TBI management.

Authors/Disclosures
Japleen Kaur, MBBS PRESENTER	Dr. Kaur has nothing to disclose.
Humza Saeed, MBBS	Mr. Saeed has nothing to disclose.
Sufyan Shahid, MBBS	Mr. Shahid has nothing to disclose.
Ayesha Batool, MBBS	Dr. Batool has nothing to disclose.
Abdullah Farooq, MBBS	Mr. Farooq has nothing to disclose.
Yasir Altaf, MBBS	Dr. Altaf has nothing to disclose.
Megha Joshi, MBBS	Dr. Joshi has received personal compensation for serving as an employee of Essen Healthcare. Dr. Joshi has received personal compensation for serving as an employee of CityMD. Dr. Joshi has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for SGS Consulting.

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