Abstract Details

Title Transportation Noise and Incident Dementia in a Nationwide Population-Based Study

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P6 - Poster Session 6 (11:45 AM-12:45 PM)

Poster/Presentation
Number 3-001

Objective To investigate the role of transportation noise on risk of incident dementia.

Background Previous studies have linked hearing loss to dementia. Despite evidence of a relationship between hearing loss and traffic noise, few studies have examined the role of transportation noise, a modifiable risk factor, on dementia risk.

Design/Methods We conducted a nationwide, population-based study of 20,789,037 Medicare beneficiaries (aged 67+), 756,321 with incident dementia. Our exposure of interest was average annual transportation noise in decibels (Db) for 2016. We used logistic regression to test the nationwide and region-specific associations between zip+4 level transportation noise and incident dementia. We adjusted for age, sex, race, cardiometabolic disease, and income neighborhood-level educational attainment as potential confounders. To assess the independent role of transportation noise (above and beyond traffic pollution), we adjusted our model for 1 km² estimates of on-road nitrogen oxides (NOx), on-road volatile organic compounds (VOCs), average annual PM_2.5 from 2000 to 2017, and average annual daily traffic for 1997-2010. We performed state-by-state models to assess the geographical variation in the relationship between dementia and transportation noise.

Results Transportation noise was associated with a dose-dependent greater risk of incident dementia nationwide. After adjusting for traffic-related air pollution (NO_x, VOCs, PM_2.5), beneficiaries who lived in neighborhoods with transportation noise greater than 200 Db had a 44% (OR=1.44, 95% CI: 1.38-1.50) greater odds of dementia compared to beneficiaries who live in neighborhoods with less than 10 Db of transportation noise. The strongest association between transportation noise and dementia was generally found in the states on the eastern half of the nation where there was a 6% (95% CI: 5%-7%) greater risk of incident dementia with every doubling of traffic noise exposure.

Conclusions Exposure to transportation noise was associated with a greater likelihood of developing dementia, above and beyond traffic pollution.

Authors/Disclosures
Brittany Krzyzanowski, PhD PRESENTER	Dr. Krzyzanowski has nothing to disclose.
Vishal Harnoor, BS	Mr. Harnoor has nothing to disclose.
Sai Shivani Chirag, MS	Miss Chirag has nothing to disclose.
George K. Karway, PhD (Barrow Neurological Institute)	Dr. Karway has nothing to disclose.
Irene Faust, MPH (Barrow Neurological Institute)	Ms. Faust has nothing to disclose.
Brad A. Racette, MD, FAAN (Barrow Neurological Institute)	Dr. Racette has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for American Regent. Dr. Racette has received personal compensation in the range of $500-$4,999 for serving as a advisory council with NIEHS.

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