Abstract Details

Title Efficacy and Safety of Amantadine for Functional Recovery in Adults with Traumatic Brain Injury: An Updated Systematic Review and Meta-analysis

Topic Neuro-rehabilitation

Presentation(s) P6 - Poster Session 6 (11:45 AM-12:45 PM)

Poster/Presentation
Number 4-002

Objective To present the results of a systematic review and meta-analysis about the efficacy and safety of amantadine to functional recovery in patients who suffered traumatic brain injury (TBI).

Background Amantadine is an antiviral drug with neuroprotective and neurostimulant properties, but its benefits on functional recovery after traumatic brain injuries are still uncertain. We aimed to perform a meta-analysis to evaluate the effects of amantadine in adults with TBI.

Design/Methods

We systematically searched PubMed (MEDLINE), EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science for randomized controlled trials (RCTs) and observational studies evaluating amantadine use in patients with TBI. Heterogeneity was examined with the Cochran Q test and I² statistics; p-values below 0.10 and I² > 25% were considered significant for heterogeneity. We performed statistical analysis with R software (version 4.4.0) with the meta package (version 7.0-0).

Results We included 7 RCTs and 4 observational studies accounting for 1273 patients of whom 459 (36%) received amantadine. The analyses yielded results comparing amantadine use with its no-use showing no difference in functional recovery (SMD -0.36; 95% CI [-0.45, 0.31]; p = 0.72; I² = 78%), epileptic seizures (RR 0.78; 95% CI [0.42, 1.44]; p = 0.43; I² = 0%), in-hospital mortality (RR 0.9; 95% CI [0.35, 2.33]; p = 0.83; I² = 48%), and gastrointestinal events (RR 1.17; 95% CI [0.95, 1.43]; p = 0.13; I² = 0%).

Conclusions There was no significant difference between amantadine and the absence of its use to improve functional recovery in the context of TBI.

Authors/Disclosures
Mateus Damiani Monteiro, MD PRESENTER	Dr. Damiani Monteiro has nothing to disclose.
Davi Orli M. Grüdtner, Medical Student	Mr. Grüdtner has nothing to disclose.
João P. Rocha, Sr., None	Mr. Rocha has nothing to disclose.
Giovanna D. Vitoria, RN	Miss Vitoria has nothing to disclose.
Maria Julia H. Moura, Medical Student	Ms. Moura has nothing to disclose.
Tamiris Dal Bó Martinello, MD	Prof. Dal Bó Martinello has nothing to disclose.
Josete Mazon, PhD	Dr. Mazon has nothing to disclose.

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