Abstract Details

Title Stratifying Clinically Relevant Risk Factors for Acute Ischemic Stroke and Cerebrovascular Events in Chagas Disease: A Systematic Review and Meta-Analysis

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P6 - Poster Session 6 (11:45 AM-12:45 PM)

Poster/Presentation
Number 13-004

Objective This study aims to systematically review and analyze the literature to identify risk factors for acute ischemic stroke (AIS) and cerebrovascular events in patients already diagnosed with Chagas Disease (CD).

Background CD poses significant health risks, including an increased incidence of AIS. However, the specific risk factors for AIS in CD patients are not welldefined.

Design/Methods We performed a systematic review and meta-analysis by searching PubMed, Embase, Web of Science, and the Cochrane Library up to August 2024. Primary outcomes evaluated in AIS patients with CD included reduced left ventricular ejection fraction (LVEF), anticoagulation therapy, atrial fibrillation (AF), left ventricular apical aneurysm (LVAA), pacemaker use, and coronary artery disease (CAD). Risk ratios (RRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model.

Results Six studies were included, involving 1,229 patients (48% male). The analysis revealed a higher risk of AIS in CD patients with reduced LVEF (RR 3.38; 95% CI 1.38 - 8.27), AF (OR 4.85; 95% CI 2.13 - 11.02), LVAA (OR 3.76; 95% CI 1.96 - 7.21), and pacemaker use (OR 2.37; 95% CI 1.38 - 4.09). Anticoagulation therapy was associated with a reduced likelihood of stroke (OR 0.28; 95% CI 0.19 - 0.41). No significant association was found between CAD and stroke risk (OR 1.56; 95% CI 0.93 - 2.59).

Conclusions Reduced LVEF, AF, LVAA, and pacemaker use are correlated with higher stroke incidence in CD patients, while anticoagulation therapy diminishes this risk. Further randomized studies are needed to refine AIS prevention strategies for this population.

Authors/Disclosures
Marina Vilardo PRESENTER	Miss Vilardo has nothing to disclose.
Ana Santos, MD	Ms. Santos has nothing to disclose.
Ocilio R. Goncalves, MS	Mr. Goncalves has nothing to disclose.
Saul Dominici, Sr.	Dr. Dominici has nothing to disclose.
Júlia dos Santos Monteiro, MS	Dr. dos Santos Monteiro has nothing to disclose.
Elizabet Taylor P. Weba, Jr., Student	Miss Weba has nothing to disclose.
Anthony Hong, MD	Dr. Hong has nothing to disclose.
Maria Tereza Camarotti, Medical Student	Ms. Camarotti has nothing to disclose.
Niels V. Pacheco, MD	Mr. Pacheco has nothing to disclose.
João Victor Araújo de Oliveira, MD	Mr. Araújo de Oliveira has nothing to disclose.
Arlindo B. Junior, MD Student	Mr. Junior has nothing to disclose.
Marcio Y. Ferreira, MD	Dr. Ferreira has nothing to disclose.
Kelson J. Almeida, PhD	Prof. Almeida has nothing to disclose.

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