Abstract Details

Title Characterizing the Role of Cardiac Biomarkers in Friedreich’s Ataxia and Establishing Demographic and Echocardiographic Correlations– A Meta-analytic Review

Topic Movement Disorders

Presentation(s) P6 - Poster Session 6 (11:45 AM-12:45 PM)

Poster/Presentation
Number 5-030

Objective Assess the cardiac serum biomarker changes in Friedreich’s Ataxia (FA) and correlate those changes to socio-demographic, disease-specific, and echocardiographic factors.

Background FA has been associated with cardiac dysfunction, particularly through biomarkers such as cardiac troponin T (cTnT), cardiac troponin I (cTnI), B-type natriuretic peptide (BNP), and Galectin-3. This study aimed to pool biomarker levels in FA patients and explore their relationships with clinical and demographic factors through a systematic review and meta-analysis.

Design/Methods On August 2, 2024, we conducted a literature search on PubMed, Scopus, and Medline. We used R software 4.4.1 for the single-armed and double-armed meta-analyses. The PRISMA guidelines were followed throughout the review.

Results Eleven studies were qualified for the systematic review, while eight studies were pooled for the meta-analysis. FA patients exhibited elevated cTnT levels, with a pooled estimate of 15.57 ng/L (95% CI [13.52, 17.62], I²: 18%), indicating a link to hypertrophic cardiomyopathy severity. There was no consistent association between cTnT and ejection fraction. Compared to healthy controls, FA patients had significantly higher BNP levels (p = 0.03), yet these levels remained non-pathological (pooled estimate: 57.36 ng/L, 95% CI [32.90, 81.82]). No correlation between BNP levels and sociodemographic or phenotypic factors was noted. CTnI levels were elevated in FA patients and estimated at 0.12 ng/ml (95% CI [0.03, 0.21], I²: 79.6%). Interestingly, cTnI serum levels were elevated despite the absence of acute cardiac symptomatology. Similarly, Galectin-3 levels were significantly elevated in FA patients compared to healthy controls (mean difference: 3.19, 95% CI [0.65, 5.73], I²: 80%), but there was no significant correlation with echocardiographic measures. No associations were established between GAA repeat length and cardiac biomarker levels.

Conclusions FA patients exhibit elevated cardiac biomarkers. However, their associations with some demographic and echocardiographic factors remain inconsistent; thus warranting further investigation into their clinical significance.

Authors/Disclosures
Nsser Abdelall, MD (LSU Health Sciences - CALS Bldg) PRESENTER	Dr. Abdelall has nothing to disclose.
Mohamed Ibrahim A. Mohamed, MD	Mr. Mohamed has nothing to disclose.
Abu Omayer, MBBS	Dr. Omayer has nothing to disclose.
Dina T. Bekhit, MD, MBBS	Dr. Bekhit has nothing to disclose.
Moussa M. Nassar	Mr. Nassar has nothing to disclose.
Alaa M. Alqadi, MBBS	Dr. Alqadi has nothing to disclose.
Yasmeen E. Yaqout, MD	Dr. Yaqout has nothing to disclose.
Roaa Taha, MD	Dr. Taha has nothing to disclose.

��ɫ��

��ɫ��